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Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice
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Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice
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Journal Article
Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice
2016
Overview
The recent Zika virus （ZIKV） epidemic in Latin America coincided with a marked increase in microcephaly in newborns. However, the causal link between maternal ZIKV infection and malformation of the fetal brain has not been firmly established. Here we show a vertical transmission of ZIKV in mice and a marked effect on fetal brain development. We found that intraperitoneal （i.p.） injection of a contemporary ZIKV strain in pregnant mice led to the infection of radial gila cells （RGs） of dorsal ventricular zone of the fetuses, the primary neural progenitors responsi- ble for cortex development, and caused a marked reduction of these cortex founder cells in the fetuses. Interestingly, the infected fetal mice exhibited a reduced cavity of lateral ventricles and a discernable decrease in surface areas of the cortex. This study thus supports l;he conclusion that vertically transmitted ZIKV affects fetal brain development and provides a valuable animal model for the evaluation of potential therapeutic or preventative strategies.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Biomedical and Life Sciences
/ Cerebral Cortex - abnormalities
/ Cerebral Cortex - embryology
/ Ependymoglial Cells - pathology
/ Ependymoglial Cells - virology
/ Neural Stem Cells - pathology
/ Original
/ Zika Virus Infection - pathology
/ Zika Virus Infection - transmission
/ Zika Virus Infection - virology
/ 后代
/ 垂直传播
/ 大脑发育
/ 小鼠
/ 放射状
/ 病毒
/ 皮质
/ 胶质细胞
