Asset Details
Do you wish to reserve the book?
Macrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter‐regulator
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Macrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter‐regulator
Do you wish to request the book?
Macrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter‐regulator
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Macrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter‐regulator
2003
Overview
In humans, maximal expression of T helper 1 cytokines coincide with the nocturnal nadir of plasma cortisol, whereas T helper 2 cytokine responses are dominant during day‐time. The pro‐inflammatory cytokine, macrophage migration inhibitory factor counter‐regulates glucocorticoid‐mediated immune suppression. To determine the relationship between cortisol and macrophage migration inhibitory factor, healthy volunteers had blood drawn hourly for 24 h for measurement of plasma cortisol and basal‐ and stimulated‐macrophage migration inhibitory factor. Similar to cortisol, macrophage migration inhibitory factor peaked during the late morning whereas interferon‐γ, tumour necrosis factor‐α, interleukin‐1 and interleukin‐12 demonstrated a nocturnal peak. After oral cortisone, plasma macrophage migration inhibitory factor rose 2–4‐fold, whereas the other cytokines decreased. There was no correlation between cortisol during the insulin tolerance test and plasma macrophage migration inhibitory factor. The late morning peak of macrophage migration inhibitory factor, by antagonizing cortisol‐mediated pro‐inflammatory cytokine suppression may prolong the duration of early morning inflammation. These observations explain the beneficial role of macrophage migration inhibitory factor neutralization in models of inflammatory arthritis.
Publisher
Nature Publishing Group,Blackwell Science Ltd
Subject
/ Bacterial Toxins - pharmacology
/ cortisol
/ cytokine
/ diurnal
/ Dose-Response Relationship, Drug
/ Female
/ Glucocorticoids - administration & dosage
/ Glucocorticoids - pharmacology
/ Humans
/ Hypoglycemia - chemically induced
/ Macrophage Migration-Inhibitory Factors - blood
/ Macrophage Migration-Inhibitory Factors - physiology
/ Male
/ MIF
/ Pituitary Gland - immunology
/ Th1
/ Th2
We currently cannot retrieve any items related to this title. Kindly check back at a later time.