Journal Article

Olmesartan for the Delay or Prevention of Microalbuminuria in Type 2 Diabetes

Ritz, Eberhard, Katayama, Shigehiro, Mimran, Albert, Januszewicz, Andrzej, Rump, Lars C, Viberti, Giancarlo, Menne, Jan, Rabelink, Ton J, Haller, Hermann, Ito, Sadayoshi, Izzo, Joseph L, Ruilope, Luis M

2011

Overview

This study investigated whether an angiotensin-receptor blocker (olmesartan) would delay microalbuminuria in patients with type 2 diabetes and normoalbuminuria. Olmesartan was associated with a delayed onset of microalbuminuria, even though blood pressure control in both groups was excellent. Diabetic nephropathy is an increasingly common cause of end-stage renal disease, 1 and the development and rate of renal deterioration are most closely related to the patient's blood pressure. Guideline committees worldwide concur that the blood pressure in patients with diabetes and chronic kidney disease should be kept at 130/80 mm Hg or less. 2 Microalbuminuria is predictive of diabetic nephropathy and premature cardiovascular disease 3 – 5 ; therefore, European and American guidelines recommend that patients with diabetes be tested for microalbuminuria. 6 , 7 Overactivity of the renin–angiotensin system has been implicated in the deterioration of renal function in patients with diabetic nephropathy and . . .

• Publisher: Massachusetts Medical Society
• Subject: Adolescent / Adult / Aged / Albuminuria - epidemiology / Albuminuria - prevention & control / Albuminuria/epidemiology/prevention & control / Angiotensin II Type 1 Receptor Blockers - adverse effects / Angiotensin II Type 1 Receptor Blockers - therapeutic use / Angiotensin II Type 1 Receptor Blockers/adverse effects/therapeutic use / Biological and medical sciences / Blood Pressure - drug effects / Cardiovascular Diseases - epidemiology / Cardiovascular Diseases - etiology / Cardiovascular Diseases - mortality / Cardiovascular Diseases/epidemiology/etiology/mortality / Coronary Disease - complications / Diabetes / Diabetes Mellitus, Type 2 - complications / Diabetes Mellitus, Type 2 - drug therapy / Diabetes Mellitus, Type 2/complications/drug therapy / Diabetes. Impaired glucose tolerance / Double-Blind Method / Endocrine pancreas. Apud cells (diseases) / Endocrinologie, métabolisme & nutrition / Endocrinology, metabolism & nutrition / Endocrinopathies / Etiopathogenesis. Screening. Investigations. Target tissue resistance / Female / Follow-Up Studies / General aspects / Glomerular Filtration Rate - drug effects / Human health sciences / Humans / Imidazoles - adverse effects / Imidazoles - therapeutic use / Kidney diseases / Male / Medical sciences / Middle Aged / Prevention and actions / Public health. Hygiene / Public health. Hygiene-occupational medicine / Sciences de la santé humaine / Tetrazoles - adverse effects / Tetrazoles - therapeutic use / Urologie & néphrologie / Urology & nephrology / Young Adult