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Targeting the PD-1/PD-L1 Axis in Human Vitiligo
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Targeting the PD-1/PD-L1 Axis in Human Vitiligo
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Targeting the PD-1/PD-L1 Axis in Human Vitiligo
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Journal Article
Targeting the PD-1/PD-L1 Axis in Human Vitiligo
2020
Overview
Autoreactive CD8
T cells play a pivotal role in melanocyte destruction in autoimmune vitiligo. Immunotherapy for melanoma often leads to autoimmune side-effects, among which vitiligo-like depigmentation, indicating that targeting immune checkpoints can break peripheral tolerance against self-antigens in the skin. Therapeutically enhancing immune checkpoint signaling by immune cells or skin cells, making self-reactive T cells anergic, seems a promising therapeutic option for vitiligo. Here, we review the current knowledge on the PD-1/PD-L1 pathway in vitiligo as new therapeutic target for vitiligo therapy.
