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Sodium-Hydrogen Exchanger Isoform-1 Inhibition: A Promising Pharmacological Intervention for Resuscitation from Cardiac Arrest
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Sodium-Hydrogen Exchanger Isoform-1 Inhibition: A Promising Pharmacological Intervention for Resuscitation from Cardiac Arrest
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Journal Article
Sodium-Hydrogen Exchanger Isoform-1 Inhibition: A Promising Pharmacological Intervention for Resuscitation from Cardiac Arrest
2019
Overview
Out-of-hospital sudden cardiac arrest is a major public health problem with an overall survival of less than 5%. Upon cardiac arrest, cessation of coronary blood flow rapidly leads to intense myocardial ischemia and activation of the sarcolemmal Na+-H+ exchanger isoform-1 (NHE-1). NHE-1 activation drives Na+ into cardiomyocytes in exchange for H+ with its exchange rate intensified upon reperfusion during the resuscitation effort. Na+ accumulates in the cytosol driving Ca2+ entry through the Na+-Ca2+ exchanger, eventually causing cytosolic and mitochondrial Ca2+ overload and worsening myocardial injury by compromising mitochondrial bioenergetic function. We have reported clinically relevant myocardial effects elicited by NHE-1 inhibitors given during resuscitation in animal models of ventricular fibrillation (VF). These effects include: (a) preservation of left ventricular distensibility enabling hemodynamically more effective chest compressions, (b) return of cardiac activity with greater electrical stability reducing post-resuscitation episodes of VF, (c) less post-resuscitation myocardial dysfunction, and (d) attenuation of adverse myocardial effects of epinephrine; all contributing to improved survival in animal models. Mechanistically, NHE-1 inhibition reduces adverse effects stemming from Na+–driven cytosolic and mitochondrial Ca2+ overload. We believe the preclinical work herein discussed provides a persuasive rationale for examining the potential role of NHE-1 inhibitors for cardiac resuscitation in humans.
Publisher
MDPI AG,MDPI
Subject
/ Calcium Signaling - drug effects
/ Calcium Signaling - genetics
/ Cardiopulmonary resuscitation
/ CPR
/ Humans
/ Ischemia
/ Myocardial Ischemia - drug therapy
/ Myocardial Ischemia - genetics
/ Myocardial Ischemia - pathology
/ Myocytes, Cardiac - metabolism
/ Myocytes, Cardiac - pathology
/ Non-pharmacological intervention
/ Review
/ Sodium-Hydrogen Exchangers - antagonists & inhibitors
/ Sodium-Hydrogen Exchangers - genetics
/ Sodium-Hydrogen Exchangers - metabolism
/ Ventricular Fibrillation - drug therapy
/ Ventricular Fibrillation - genetics
