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SF3B4 Plays an Oncogenic Role in Esophageal Squamous Cell Carcinoma

by NAMBARA, SHO , SATO, KUNIAKI , UEDA, MASAMI , HU, QUINGJANG , MORI, MASAKI , YOSHIKAWA, YUKIHIRO , KOMATSU, HISATERU , IGUCHI, TOMOHIRO , DOKI, YUICHIRO , KIDOGAMI, SHINYA , KURODA, YOSUKE , MASUDA, TAKAAKI , MIMORI, KOSHI

in Cancer / Carcinogenesis / Carcinogens / Cell cycle / Copy number / Datasets / E2F protein / Esophageal cancer / Esophageal carcinoma / Gene expression / Gene set enrichment analysis / Liver cancer / Lymphatic system / Medical prognosis / Metastasis / Overexpression / Polymerase chain reaction / Real time / Reverse transcription / Splicing factors / Squamous cell carcinoma / Tumorigenesis

2020

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SF3B4 Plays an Oncogenic Role in Esophageal Squamous Cell Carcinoma

2020

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SF3B4 Plays an Oncogenic Role in Esophageal Squamous Cell Carcinoma

2020

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Journal Article

SF3B4 Plays an Oncogenic Role in Esophageal Squamous Cell Carcinoma

NAMBARA, SHO,

SATO, KUNIAKI,

UEDA, MASAMI,

HU, QUINGJANG,

MORI, MASAKI,

YOSHIKAWA, YUKIHIRO,

KOMATSU, HISATERU,

IGUCHI, TOMOHIRO,

DOKI, YUICHIRO,

KIDOGAMI, SHINYA,

KURODA, YOSUKE,

MASUDA, TAKAAKI,

MIMORI, KOSHI

2020

Overview

The spliceosome pathway, including Splicing Factor 3b Subunit 4 (SF3B4), plays an important role in carcinogenesis and progression in various cancers; however, the clinical relevance of SF3B4 in esophageal squamous cell carcinoma (ESCC) remains unknown. SF3B4 expression was evaluated by real-time reverse transcription polymerase chain reaction in 80 ESCC patients. In order to explore the mechanism of SF3B4 in ESCC, the mRNA expression and copy number of SF3B4 were obtained from TCGA and we also implemented gene set enrichment analysis (GSEA). The high SF3B4 expression group (n=33) showed significantly more lymphatic permeation and poorer prognosis than the low SF3B4 expression group (n=47). GSEA revealed that high SF3B4 expression was correlated with genes associated with the transcription factor E2F and the G /M checkpoint. SF3B4 expression was positively correlated with SF3B4 DNA copy number. Over-expression of SF3B4 may play a crucial role in the lymphatic progression of ESCC.

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International Institute of Anticancer Research

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