Asset Details
Do you wish to reserve the book?
Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis
Do you wish to request the book?
Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis
2022
Overview
Non-invasive imaging modalities constitute an increasingly important tool in diagnostic and therapy response monitoring of patients with autoimmune diseases, including rheumatoid arthritis (RA). In particular, macrophage imaging with positron emission tomography (PET) using novel radiotracers based on differential expression of plasma membrane proteins and functioning of cellular processes may be suited for this. Over the past decade, selective expression of folate receptor β (FRβ), a glycosylphosphatidylinositol-anchored plasma membrane protein, on myeloid cells has emerged as an attractive target for macrophage imaging by exploiting the high binding affinity of folate-based PET tracers. This work discusses molecular, biochemical and functional properties of FRβ, describes the preclinical development of a folate-PET tracer and the evaluation of this tracer in a translational model of arthritis for diagnostics and therapy-response monitoring, and finally the first clinical application of the folate-PET tracer in RA patients with active disease. Consequently, folate-based PET tracers hold great promise for macrophage imaging in a variety of (chronic) inflammatory (autoimmune) diseases beyond RA.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Arthritis, Rheumatoid - diagnostic imaging
/ Arthritis, Rheumatoid - drug therapy
/ Arthritis, Rheumatoid - metabolism
/ Drugs
/ Folate Receptor 2 - metabolism
/ Folic Acid Antagonists - pharmacology
/ Folic Acid Antagonists - therapeutic use
/ Glycosylphosphatidylinositol
/ Humans
/ Positron emission tomography
/ Proteins
