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The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy
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The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy
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Journal Article
The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy
2019
Overview
Herein, a convergent, practicable and first total synthesis of the natural product, (±)-methyl salvianolate A, is reported. The key features of the approach are the use of a Horner–Wadsworth–Emmons reaction and the protection of multiple hydroxyls using silyl protecting groups. The employment of the readily removable silyl protecting groups allows the synthesis of (±)-methyl salvianolate A and its derivatives on a reasonably large scale.
Publisher
MDPI AG,MDPI
