Asset Details
Do you wish to reserve the book?
The Emerging Role of Microglia in Neuromyelitis Optica
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The Emerging Role of Microglia in Neuromyelitis Optica
Do you wish to request the book?
The Emerging Role of Microglia in Neuromyelitis Optica
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The Emerging Role of Microglia in Neuromyelitis Optica
2021
Overview
Neuromyelitis optica (NMO) is an autoantibody-triggered neuro-inflammatory disease which preferentially attacks the spinal cord and optic nerve. Its defining autoantibody is specific for the water channel protein, aquaporin‐4 (AQP4), which primarily is localized at the end-feet of astrocytes. Histopathology studies of early NMO lesions demonstrated prominent activation of microglia, the resident immune sentinels of the central nervous system (CNS). Significant microglial reactivity is also observed in NMO animal models induced by introducing AQP4-IgG into the CNS. Here we review the potential roles for microglial activation in human NMO patients as well as different animal models of NMO. We will focus primarily on the molecular mechanisms underlying microglial function and microglia-astrocyte interaction in NMO pathogenesis. Understanding the role of microglia in NMO pathology may yield novel therapeutic approaches for this disease.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Animals
/ astrocyte-microglia communication
/ Complement System Proteins - immunology
/ Complement System Proteins - metabolism
/ Disease Susceptibility - immunology
/ Humans
/ Neuromyelitis Optica - etiology
/ Neuromyelitis Optica - metabolism
/ Neuromyelitis Optica - pathology
/ Rodentia
/ Rodents
