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HSPA6 is Correlated With the Malignant Progression and Immune Microenvironment of Gliomas

by Luo, Min , Wang, Peng , Ye, Minhua , Xiao, Feng , Li, Qin , Zhou, Xiang , Lin, Li , Guo, Hua , Guo, Yun , Hu, Guowen , Wu, Weijun , Huang, Kai , Ji, Qiankun

in Angiogenesis / Apoptosis / Biomarkers / Brain cancer / Brain tumors / Cancer therapies / Cell and Developmental Biology / Cell proliferation / Datasets / experimental validation / Genes / Genomes / Glioblastoma / Glioma / Glioma cells / gliomas / heat shock protein family A member 6 (HSPA6) / Heat shock proteins / Hsp70 protein / Immunity / malignancy / Medical prognosis / Mutation / Prognosis / Regression analysis / Survival analysis / Therapeutic targets / tumor immune microenvironment / Tumor microenvironment / Tumors

2022

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HSPA6 is Correlated With the Malignant Progression and Immune Microenvironment of Gliomas

by Luo, Min , Wang, Peng , Ye, Minhua , Xiao, Feng , Li, Qin , Zhou, Xiang , Lin, Li , Guo, Hua , Guo, Yun , Hu, Guowen , Wu, Weijun , Huang, Kai , Ji, Qiankun

2022

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HSPA6 is Correlated With the Malignant Progression and Immune Microenvironment of Gliomas

by Luo, Min , Wang, Peng , Ye, Minhua , Xiao, Feng , Li, Qin , Zhou, Xiang , Lin, Li , Guo, Hua , Guo, Yun , Hu, Guowen , Wu, Weijun , Huang, Kai , Ji, Qiankun

2022

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Journal Article

HSPA6 is Correlated With the Malignant Progression and Immune Microenvironment of Gliomas

Luo, Min,

Wang, Peng,

Ye, Minhua,

Xiao, Feng,

Li, Qin,

Zhou, Xiang,

Lin, Li,

Guo, Hua,

Guo, Yun,

Hu, Guowen,

Wu, Weijun,

Huang, Kai,

Ji, Qiankun

2022

Overview

Gliomas are primary intracranial space lesions with a high mortality rate. Current treatments for glioma are very limited. Recently, immunotargeted therapy of the glioma microenvironment has been developed. Members of the 70 kDa heat shock protein (HSP70) family are involved in the development of many tumors and immunity. HSPA6 protein belongs to the HSP70 family; However, the biological function of this protein in gliomas has yet to be evaluated. In the present study, a range of analyses, involving protein networks, survival, clinical correlation, and function, revealed that the expression of HSPA6 was negatively correlated with clinical prognosis and closely associated with immunity, invasion, and angiogenesis. Quantitative protein analysis confirmed that HSPA6 was expressed at high levels in patients with glioblastoma. Vitro experiments further verified that HSPA6 enhanced the malignant progression of glioma cells by promoting proliferation, invasion and anti-apoptosis. We also found that HSPA6 was closely correlated with genomic variations and tumor microenvironment. Collectively, we demonstrated that HSPA6 may represent a new therapeutic target to improve the prognosis of patients with gliomas.

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Publisher

Frontiers Media SA,Frontiers Media S.A

Subject

/ Cell and Developmental Biology