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Periodontitis-Derived Dark-NETs in Severe Covid-19

by Krunić, Jelena , Herrmann, Martin , Minnich, Bernd , Vitkov, Ljubomir , Knopf, Jasmin , Schauer, Christine , Schoen, Janina , Hannig, Matthias

in Cardiovascular diseases / Chemokines / Comorbidity / COVID-19 / Cytokines / Deoxyribonuclease / Diabetes mellitus / dysregulated immunity / Endotoxemia / Endotoxemia - metabolism / Extracellular Traps / Gum disease / Humans / Immunity (Disease) / Immunology / Inflammation / inhibition of NET formation / Innate immunity / Leukocytes (neutrophilic) / Lipopolysaccharides / Lipopolysaccharides - metabolism / Lupus / NET hyper-responsiveness / NET-induced damage / neutrophil hyper-responsiveness / Neutrophils / Pathogens / Periodontitis / Periodontitis - pathology / Proteins / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus 2 / Spike Glycoprotein, Coronavirus / Spike protein / trained immunity

2022

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Periodontitis-Derived Dark-NETs in Severe Covid-19

by Krunić, Jelena , Herrmann, Martin , Minnich, Bernd , Vitkov, Ljubomir , Knopf, Jasmin , Schauer, Christine , Schoen, Janina , Hannig, Matthias

2022

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Periodontitis-Derived Dark-NETs in Severe Covid-19

by Krunić, Jelena , Herrmann, Martin , Minnich, Bernd , Vitkov, Ljubomir , Knopf, Jasmin , Schauer, Christine , Schoen, Janina , Hannig, Matthias

2022

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Journal Article

Periodontitis-Derived Dark-NETs in Severe Covid-19

Krunić, Jelena,

Herrmann, Martin,

Minnich, Bernd,

Vitkov, Ljubomir,

Knopf, Jasmin,

Schauer, Christine,

Schoen, Janina,

Hannig, Matthias

2022

Overview

The frequent severe COVID-19 course in patients with periodontitis suggests a link of the aetiopathogenesis of both diseases. The formation of intravascular neutrophil extracellular traps (NETs) is crucial to the pathogenesis of severe COVID-19. Periodontitis is characterised by an increased level of circulating NETs, a propensity for increased NET formation, delayed NET clearance and low-grade endotoxemia (LGE). The latter has an enormous impact on innate immunity and susceptibility to infection with SARS-CoV-2. LPS binds the SARS-CoV-2 spike protein and this complex, which is more active than unbound LPS, precipitates massive NET formation. Thus, circulating NET formation is the common denominator in both COVID-19 and periodontitis and other diseases with low-grade endotoxemia like diabetes, obesity and cardiovascular diseases (CVD) also increase the risk to develop severe COVID-19. Here we discuss the role of propensity for increased NET formation, DNase I deficiency and low-grade endotoxaemia in periodontitis as aggravating factors for the severe course of COVID-19 and possible strategies for the diminution of increased levels of circulating periodontitis-derived NETs in COVID-19 with periodontitis comorbidity.

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Publisher

Frontiers Media SA,Frontiers Media S.A

Subject

Cardiovascular diseases