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Drug resistance and tolerance in fungi
by
Krysan, Damian J
, Berman, Judith
in
Antifungal agents
/ Antifungal Agents - pharmacology
/ Candida - drug effects
/ Care and treatment
/ Caspofungin
/ Discordance
/ Drug resistance
/ Drug Resistance, Fungal
/ Drug Tolerance
/ Fungi
/ Fungicides
/ Health aspects
/ Humans
/ Infection
/ Medical colleges
/ Methicillin
/ Microbial Sensitivity Tests
/ Mycoses
/ Physiological aspects
/ Physiology
2020
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Drug resistance and tolerance in fungi
by
Krysan, Damian J
, Berman, Judith
in
Antifungal agents
/ Antifungal Agents - pharmacology
/ Candida - drug effects
/ Care and treatment
/ Caspofungin
/ Discordance
/ Drug resistance
/ Drug Resistance, Fungal
/ Drug Tolerance
/ Fungi
/ Fungicides
/ Health aspects
/ Humans
/ Infection
/ Medical colleges
/ Methicillin
/ Microbial Sensitivity Tests
/ Mycoses
/ Physiological aspects
/ Physiology
2020
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Do you wish to request the book?
Drug resistance and tolerance in fungi
by
Krysan, Damian J
, Berman, Judith
in
Antifungal agents
/ Antifungal Agents - pharmacology
/ Candida - drug effects
/ Care and treatment
/ Caspofungin
/ Discordance
/ Drug resistance
/ Drug Resistance, Fungal
/ Drug Tolerance
/ Fungi
/ Fungicides
/ Health aspects
/ Humans
/ Infection
/ Medical colleges
/ Methicillin
/ Microbial Sensitivity Tests
/ Mycoses
/ Physiological aspects
/ Physiology
2020
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Journal Article
Drug resistance and tolerance in fungi
2020
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Overview
Systemic fungal infections pose a serious clinical problem. Treatment options are limited, and antifungal drug resistance is increasing. In addition, a substantial proportion of patients do not respond to therapy despite being infected with fungi that are susceptible to the drug. The discordance between overall treatment outcome and low levels of clinical resistance may be attributable to antifungal drug tolerance. In this Review, we define and distinguish resistance and tolerance and discuss the current understanding of the molecular, genetic and physiological mechanisms that contribute to those phenomena. Distinguishing tolerance from resistance might provide important insights into the reasons for treatment failure in some settings.
Publisher
Nature Publishing Group
Subject
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