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Isolation, total synthesis, and biological evaluation of dearomatized isoprenylated acylphloroglucinols from Hypericum przewalskii
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Isolation, total synthesis, and biological evaluation of dearomatized isoprenylated acylphloroglucinols from Hypericum przewalskii
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Journal Article
Isolation, total synthesis, and biological evaluation of dearomatized isoprenylated acylphloroglucinols from Hypericum przewalskii
2026
Overview
New dearomatized isoprenylated acylphloroglucinols hyperprzewones A (
1
) and B (
2
) were isolated and characterized from the dried aerial parts of
Hypericum przewalskii
. The structures of these compounds were confirmed by extensive spectroscopic experiments. A facile synthetic route to
1
and
2
was developed via Friedel-Crafts acylation, alkylation, dearomatization, and oxidative [4 + 2] cyclization, giving a 17% overall yield. Moreover, the synthetic derivative
8
exhibited moderate inhibition on T-type calcium channels Ca
v
3.2.
Graphical Abstract
Publisher
Springer Nature Singapore,Springer Nature B.V,Springer,SpringerOpen
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