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A community-led initiative to de-risk and advance Parkinson’s disease therapeutic targets

by Birol, Ryan , Riley, Ekemini , Ryten, Mina , St. Clair, Lara , Vaiana, Alexandra , Miller, Julie E. , Ducotterd, Fiona , Navarro, Grace , Polinski, Nicole , Schoepp, Darryle , Skibinski, Gaia , Dunlop, John , Logsdon, Bejamin A. , Leuchter, Bruce , Padmanabhan, Shalini , Weninger, Stacie , Singleton, Andrew , Tinelli, Elisa , Rubin, Lee , Knight, Adam , Wood, Stephen , Mukherjee, Pooja , Wang, Yifei , Rastegar-Pouyani, Shima , Reith, Alastair D. , Fiske, Brian , Citron, Martin , Stoehr, Jan , Nelson, Matthew R. , Hannestad, Jonas , Buggia-Prevot, Virginie , Sadick, Jessica , Koemeter-Cox, Andrew , Tanenbaum, Nicole , Crapser, Joshua , Mitchell, Amanda , Sherer, Todd , Casey, Bradford , Chowdhury, Kushan , Trimble, Kate , Kleiman, Robin , Kemp, Jennifer , Wiggenhauser, Nicolás , Sullivan, Julianna , Otis, Tom , Dumanis, Sonya , Stone, David J. , Dardov, Victoria , Behr, Jonathan , Blauwendraat, Cornelis , Marreiros, Rita , Silvergleid, Sarah , Hung, Wendy , Schwabe, Tina , Golden, Jessica , Nikolich, Karoly , Durborow, Michelle

in 631/154 / 631/378 / Biology / Biomedical and Life Sciences / Biomedicine / Biotechnology industry / Drug development / Due diligence / Neurology / Neurosciences / Nominations / Parkinson's disease / Perspective / Venture capital

2025

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2025

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2025

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Journal Article

A community-led initiative to de-risk and advance Parkinson’s disease therapeutic targets

Birol, Ryan,

Riley, Ekemini,

Ryten, Mina,

St. Clair, Lara,

Vaiana, Alexandra,

Miller, Julie E.,

Ducotterd, Fiona,

Navarro, Grace,

Polinski, Nicole,

Schoepp, Darryle,

Skibinski, Gaia,

Dunlop, John,

Logsdon, Bejamin A.,

Leuchter, Bruce,

Padmanabhan, Shalini,

Weninger, Stacie,

Singleton, Andrew,

Tinelli, Elisa,

Rubin, Lee,

Knight, Adam,

Wood, Stephen,

Mukherjee, Pooja,

Wang, Yifei,

Rastegar-Pouyani, Shima,

Reith, Alastair D.,

Fiske, Brian,

Citron, Martin,

Stoehr, Jan,

Nelson, Matthew R.,

Hannestad, Jonas,

Buggia-Prevot, Virginie,

Sadick, Jessica,

Koemeter-Cox, Andrew,

Tanenbaum, Nicole,

Crapser, Joshua,

Mitchell, Amanda,

Sherer, Todd,

Casey, Bradford,

Chowdhury, Kushan,

Trimble, Kate,

Kleiman, Robin,

Kemp, Jennifer,

Wiggenhauser, Nicolás,

Sullivan, Julianna,

Otis, Tom,

Dumanis, Sonya,

Stone, David J.,

Dardov, Victoria,

Behr, Jonathan,

Blauwendraat, Cornelis,

Marreiros, Rita,

Silvergleid, Sarah,

Hung, Wendy,

Schwabe, Tina,

Golden, Jessica,

Nikolich, Karoly,

Durborow, Michelle

2025

Overview

Identifying effective therapeutic targets for Parkinson’s disease (PD) is challenging, with no current disease-modifying therapies available. To address this, The Michael J. Fox Foundation for Parkinson’s Research launched the Targets to Therapies (T2T) initiative, uniting experts to prioritize and validate promising targets. T2T aims to develop validation strategies, create comprehensive target data profiles, and build tools to support drug development, ultimately accelerating the discovery of new therapies for PD patients.

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Publisher

Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio

Subject

631/154

/ 631/378

/ Biology

/ Biomedical and Life Sciences

/ Biomedicine

/ Biotechnology industry

/ Drug development