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Differences in age-related distribution of CSF alpha-synuclein seeding and Alzheimer profiles between PD with and without GBA1 variants
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Differences in age-related distribution of CSF alpha-synuclein seeding and Alzheimer profiles between PD with and without GBA1 variants
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Journal Article
Differences in age-related distribution of CSF alpha-synuclein seeding and Alzheimer profiles between PD with and without GBA1 variants
2025
Overview
We studied the age- and genetic-related prevalence of CSF alpha-Synuclein seeding and Alzheimer profiles in 188 samples from PD participants without
GBA1
variants (PD
wildtype
) and in 129 samples from PD participants with
GBA1
variants (PD
GBA1
). While Alzheimer profiles increased with age in PD
wildtype
, it was sparse in PD
GBA1
. Alpha-Synuclein profiles remained stable with age in both cohorts. In PD
wildtype
, combined alpha-Synuclein/Alzheimer profiles were associated with earlier onset of cognitive impairment.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
