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Investigating the population structure of Moraxella catarrhalis using a cgMLST scheme and LIN code system
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Journal Article
Investigating the population structure of Moraxella catarrhalis using a cgMLST scheme and LIN code system
2025
Overview
Moraxella catarrhalis
is an important cause of infectious exacerbations of chronic obstructive pulmonary disease and otitis media. To investigate the population structure of
M. catarrhalis
, we developed a core-genome multilocus sequence typing (cgMLST) scheme using 1319 core genes, and a life identification number (LIN) barcode classification system. Whole-genome analyses of nearly 2000 genomes confirmed divergent seroresistant (SR) and serosensitive (SS)
M. catarrhalis
lineages with distinct evolutionary trajectories. SR genomes are more conserved, while SS genomes exhibited greater genetic variability. Virulence gene analyses revealed lineage-specific variations in ubiquitous surface proteins (UspA1 and UspA2) and lipooligosaccharide (LOS) types. The
bro
β-lactamase, and
mcb
bacteriocin cluster, are more common in SR lineages, which suggested different selective pressures and adaptation. Here, we show that this cgMLST scheme and LIN code system provide a robust method for characterising
M. catarrhalis
, distinguish between SR and SS lineages, and offer a unified framework for population structure analyses.
This study introduces a genomic typing system for
Moraxella catarrhalis
, revealing two major lineages with distinct evolution, variability, and virulence traits.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 45/22
/ 45/23
/ Bacterial Proteins - genetics
/ Chronic obstructive pulmonary disease
/ Datasets
/ Genome, Bacterial - genetics
/ Genomes
/ Humanities and Social Sciences
/ Humans
/ Moraxella catarrhalis - classification
/ Moraxella catarrhalis - drug effects
/ Moraxella catarrhalis - genetics
/ Moraxella catarrhalis - pathogenicity
/ Moraxellaceae Infections - microbiology
/ Multilocus Sequence Typing - methods
/ Science
