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Bioactive secondary metabolites from endophytic strains of Neocamarosporium betae collected from desert plants
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Bioactive secondary metabolites from endophytic strains of Neocamarosporium betae collected from desert plants
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Journal Article
Bioactive secondary metabolites from endophytic strains of Neocamarosporium betae collected from desert plants
2023
Overview
Endophytic fungi from desert plants belong to a unique microbial community that has been scarcely investigated chemically and could be a new resource for bioactive natural products. In this study, 13 secondary metabolites ( 1–13 ) with diverse carbon skeletons, including a novel polyketide (1) with a unique 5,6-dihydro-4 H ,7 H -2,6-methanopyrano[4,3- d ][1,3]dioxocin-7-one ring system and three undescribed polyketides ( 2 , 7 , and 11 ), were obtained from the endophytic fungus Neocamarosporium betae isolated from two desert plant species. Different approaches, including HR-ESI-MS, UV spectroscopy, IR spectroscopy, NMR, and CD, were used to determine the planar and absolute configurations of the compounds. The possible biosynthetic pathways were proposed based on the structural characteristics of compounds 1–13 . Compounds 1 , 3 , 4 , and 9 exhibited strong cytotoxicity toward HepG2 cells compared with the positive control. Several metabolites ( 2 , 4–5 , 7–9 , and 11–13 ) were phytotoxic to foxtail leaves. The results support the hypothesis that endophytic fungi from special environments, such as desert areas, produce novel bioactive secondary metabolites.
