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A shared mechanism for Bacteroidota protein transport and gliding motility
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A shared mechanism for Bacteroidota protein transport and gliding motility
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Journal Article
A shared mechanism for Bacteroidota protein transport and gliding motility
2025
Overview
Bacteria of the phylum Bacteroidota are major human commensals and pathogens in addition to being abundant members of the wider biosphere. Bacteroidota move by gliding and they export proteins using the Type 9 Secretion System (T9SS). Here we discover that gliding motility and the T9SS share an unprecedented mechanism of energisation in which outer membrane proteins are covalently attached by disulfide bonds to a moving internal track structure that propels them laterally through the membrane. We determined the structure of an exemplar Bacteroidota mobile track by obtaining the cryoEM structure of a 3 MDa circular mini-track from
Porphyromonas gingivalis
. Our discoveries identify a mechanistic and evolutionary link between gliding motility and T9SS-dependent protein transport.
Bacteria of the phylum
Bacteroidota
move by gliding and export proteins using a type-9 secretion system. Here, Liu et al. show that these two processes use a shared mechanism in which outer membrane proteins are covalently attached by disulfide bonds to a moving track structure inside the cell.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/34
/ Bacteria
/ Bacterial Outer Membrane Proteins - metabolism
/ Bacterial Proteins - metabolism
/ Bacterial Secretion Systems - metabolism
/ Gliding
/ Humanities and Social Sciences
/ Motility
/ Porphyromonas gingivalis - metabolism
/ Porphyromonas gingivalis - physiology
/ Protein Transport - physiology
/ Proteins
/ Science
