Journal Article

Spectral EEG correlations from the different phases of general anesthesia

Sun, Christophe, Holcman, David, Longrois, Dan

2023

Overview

Electroencephalography (EEG) signals contain transient oscillation patterns commonly used to classify brain states in responses to action, sleep, coma or anesthesia. Using a time-frequency analysis of the EEG, we search for possible causal correlations between the successive phases of general anesthesia. We hypothesize that it could be possible to anticipate recovery patterns from the induction or maintenance phases. For that goal, we track the maximum power of the α-band and follow its time course. We quantify the frequency shift of the α-band during the recovery phase and the associated duration. Using Pearson coefficient and Bayes factor, we report non-significant linear correlation between the α-band frequency and duration shifts during recovery and the presence of the δ or the α rhythms during the maintenance phase. We also found no correlations between the α-band emergence trajectory and the total duration of the flat EEG epochs (iso-electric suppressions) induced by a propofol bolus injected during induction. Finally, we quantify the instability of the α-band using the mathematical total variation that measures possible deviations from a flat line. To conclude, the present correlative analysis shows that EEG dynamics extracted from the initial and maintenance phases of general anesthesia cannot anticipate both the emergence trajectory and the extubation time.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: alpha rhythms / Consciousness / correlation analysis / EEG segmentation / Electrodes / Electroencephalography / Fourier transforms / General anesthesia / iso-electric suppressions / Medicine / optimal fit / time-frequency analysis