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VEGF and the quest for tumour angiogenesis factors
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Journal Article
VEGF and the quest for tumour angiogenesis factors
2002
Overview
The ability of tumours to induce new blood-vessel formation has been a major focus of cancer research over the past few decades, and vascular endothelial growth factor (VEGF) is now known to be central to this process. The quest for VEGF and other factors that promote tumour angiogenesis was initiated many decades ago, and a long and complicated path has led to the development of inhibitors of these molecules as anticancer agents. How did this field begin, and how have we arrived at our present understanding of the role of VEGF in tumour progression.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Biomedical and Life Sciences
/ Control
/ DNA, Complementary - metabolism
/ Endothelial Growth Factors - metabolism
/ Endothelial Growth Factors - physiology
/ Humans
/ Intercellular Signaling Peptides and Proteins - metabolism
/ Intercellular Signaling Peptides and Proteins - physiology
/ Mice
/ Neovascularization, Pathologic
/ Rabbits
/ timeline
/ Vascular endothelial growth factor
