Journal Article

Sterile inflammation of peritoneal membrane caused by peritoneal dialysis: focus on the communication between immune cells and peritoneal stroma

An, Ning, Yang, Chen, Liu, Huafeng, Zou, Rong, Yang, Haijuan, Tang, Jixin, Chen, Xiaocui, Su, Hongyong, Su, Jinqi, Yao, Cuiwei

2024

Overview

Peritoneal dialysis is a widely used method for treating kidney failure. However, over time, the peritoneal structure and function can deteriorate, leading to the failure of this therapy. This deterioration is primarily caused by infectious and sterile inflammation. Sterile inflammation, which is inflammation without infection, is particularly concerning as it can be subtle and often goes unnoticed. The onset of sterile inflammation involves various pathological processes. Peritoneal cells detect signals that promote inflammation and release substances that attract immune cells from the bloodstream. These immune cells contribute to the initiation and escalation of the inflammatory response. The existing literature extensively covers the involvement of different cell types in the sterile inflammation, including mesothelial cells, fibroblasts, endothelial cells, and adipocytes, as well as immune cells such as macrophages, lymphocytes, and mast cells. These cells work together to promote the occurrence and progression of sterile inflammation, although the exact mechanisms are not fully understood. This review aims to provide a comprehensive overview of the signals from both stromal cells and components of immune system, as well as the reciprocal interactions between cellular components, during the initiation of sterile inflammation. By understanding the cellular and molecular mechanisms underlying sterile inflammation, we may potentially develop therapeutic interventions to counteract peritoneal membrane damage and restore normal function.

• Publisher: Frontiers Media SA,Frontiers Media S.A
• Subject: Adipocytes / Animals / Blood vessels / Cell Communication - immunology / Cell interactions / Cytokines / Endothelial cells / Fibroblasts / Glucose / Hemodialysis / Humans / immune cells / Immune system / Immunology / Inflammation / Inflammation - immunology / Kinases / Lymphocytes / Macrophages / Mast cells / mesothelial cells / Mitochondria / Mitochondrial DNA / Molecular modelling / non-bioincompatible / Oxidative stress / Peritoneal dialysis / Peritoneal Dialysis - adverse effects / peritoneal dialysis fluids / Peritoneum / Peritoneum - immunology / Peritoneum - pathology / Peritonitis / Peritonitis - immunology / Proteins / Quality of life / Recovery of function / Renal failure / sterile inflammation / Stromal cells / Stromal Cells - immunology / Structure-function relationships / Therapeutic applications / Tumor necrosis factor-TNF