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Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues
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Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues
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Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues
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Journal Article
Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues
2018
Overview
Iron is involved in processes involving oxygen transfer and utilization. Excess iron is linked to cardiovascular diseases and some types of cancer. Iron overload is associated with oxidative stress development, and may have important interactions with lipid metabolism in the liver favoring the development and progression of non-alcoholic fatty liver disease. The aim of the study described here was to assess the effect of high intake of iron on oxidative stress-related parameters, lipid metabolism, and levels of long-chain polyunsaturated fatty acids (LCPUFAs) in liver and other tissues of the rat.
Male Wistar rats (21 d old) were fed an iron-rich diet (200 mg iron/kg diet, IRD) versus a control diet (50 mg iron/kg diet; CD) for 21 d. Samples of erythrocytes, liver, adipose tissue, brain, heart, and testicles were evaluated for fatty acid composition and hepatic biochemical and oxidative stress parameters, Δ-6 and Δ-5 desaturase activities, SREBP-1c and PPAR-α mRNA expression and DNA-binding capacity, and lipolytic, lipogenic, and antioxidant enzymatic activities.
The IRD caused liver steatosis and increased activity of plasma transaminases, with higher oxidative stress status in plasma and liver. Liver Δ-6 and Δ-5 desaturase exhibited decreased activity, but enhanced expression in response to the IRD compared with the CD, with lower levels of ω-3 and ω-6 LCPUFAs and higher expression and DNA binding of SREBP-1c, whereas expression and DNA-binding activity of PPAR-α were diminished.
IRD induced oxidative stress and a reduction in the desaturation capacity of the liver, with LCPUFA depletion in the different tissues studied, thus promoting a pro-steatotic condition in the liver.
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•Iron is involved in processes concerning oxygen transfer and utilization.•Iron's role in the organism is based on its functioning as an oxygen carrier and participation in redox reactions.•An iron-rich diet induced oxidative stress and reduction in the desaturation capacity of the liver.•An iron-rich diet induced long-chain polyunsaturated fatty acid depletion in different tissues, with promotion of a pro-steatotic condition in the liver.
Publisher
Elsevier Inc,Elsevier Limited
Subject
/ Animals
/ Brain
/ Cancer
/ Chains
/ Diet
/ DNA
/ Enzymes
/ Fatty Acid Desaturases - genetics
/ Fatty Acid Desaturases - metabolism
/ Fatty Acids, Omega-3 - blood
/ Fatty Acids, Omega-6 - blood
/ Glutathione Peroxidase - genetics
/ Glutathione Peroxidase - metabolism
/ Glutathione Reductase - genetics
/ Glutathione Reductase - metabolism
/ Iron
/ Iron - administration & dosage
/ Iron Overload - physiopathology
/ Linoleoyl-CoA Desaturase - genetics
/ Linoleoyl-CoA Desaturase - metabolism
/ Lipids
/ Liver
/ Liver Δ-6/Δ-5 desaturase activity
/ Male
/ Non-alcoholic Fatty Liver Disease - blood
/ Non-alcoholic Fatty Liver Disease - etiology
/ Peroxisome proliferator-activated receptors
/ Proteins
/ Rats
/ Reactive Oxygen Species - metabolism
/ Rodents
/ Sterol Regulatory Element Binding Protein 1 - genetics
/ Sterol Regulatory Element Binding Protein 1 - metabolism
/ Sterol regulatory element-binding protein
/ Superoxide Dismutase - genetics
/ Superoxide Dismutase - metabolism
