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Transformation of macrophages into myofibroblasts in fibrosis-related diseases: emerging biological concepts and potential mechanism

by Tang, Yongjun , Xia, Zhaoyi , Li, Xiujun , Liu, Yuyan

in Animals / Bone marrow / Classification / Connective tissue / Cytokines / Defense / Fibrosis / Genotype & phenotype / Humans / Immune response / Immunity (Disease) / Immunology / Liver / Lung diseases / macrophage-to-myofibroblast transformation (MMT) / Macrophages / Macrophages - immunology / Macrophages - metabolism / Microenvironments / Molecular modelling / myofibroblasts / Myofibroblasts - immunology / Myofibroblasts - metabolism / Myofibroblasts - pathology / Pathogens / Physiology / Pulmonary Fibrosis - etiology / Pulmonary Fibrosis - immunology / Pulmonary Fibrosis - metabolism / Pulmonary Fibrosis - pathology / Signal Transduction / Skeletal muscle / Stem cells / TGF-β signaling pathway / Transforming Growth Factor beta - metabolism / Transforming growth factor-b / Wound healing

2024

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Transformation of macrophages into myofibroblasts in fibrosis-related diseases: emerging biological concepts and potential mechanism

by Tang, Yongjun , Xia, Zhaoyi , Li, Xiujun , Liu, Yuyan

2024

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Transformation of macrophages into myofibroblasts in fibrosis-related diseases: emerging biological concepts and potential mechanism

by Tang, Yongjun , Xia, Zhaoyi , Li, Xiujun , Liu, Yuyan

2024

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Journal Article

Transformation of macrophages into myofibroblasts in fibrosis-related diseases: emerging biological concepts and potential mechanism

Tang, Yongjun,

Xia, Zhaoyi,

Li, Xiujun,

Liu, Yuyan

2024

Overview

Macrophage-myofibroblast transformation (MMT) transforms macrophages into myofibroblasts in a specific inflammation or injury microenvironment. MMT is an essential biological process in fibrosis-related diseases involving the lung, heart, kidney, liver, skeletal muscle, and other organs and tissues. This process consists of interacting with various cells and molecules and activating different signal transduction pathways. This review deeply discussed the molecular mechanism of MMT, clarified crucial signal pathways, multiple cytokines, and growth factors, and formed a complex regulatory network. Significantly, the critical role of transforming growth factor-β (TGF-β) and its downstream signaling pathways in this process were clarified. Furthermore, we discussed the significance of MMT in physiological and pathological conditions, such as pulmonary fibrosis and cardiac fibrosis. This review provides a new perspective for understanding the interaction between macrophages and myofibroblasts and new strategies and targets for the prevention and treatment of MMT in fibrotic diseases.

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Publisher

Frontiers Media SA,Frontiers Media S.A

Subject

/ Defense