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Amyloid beta plaque accumulation with longitudinal 18FAZD4694 PET

by Vitali, Paolo , Fernandez‐Arias, Jaime , Massarweh, Gassan , Stevenson, Jenna , Vermeiren, Marie , Tissot, Cécile , Servaes, Stijn , Pascoal, Tharick A. , Pallen, Vanessa , Chamoun, Mira , Saha‐Chaudhuri, Paramita , Wang, Yi‐Ting , Rahmouni, Nesrine , Kunach, Peter , Bezgin, Gleb , Gauthie, Serge , Rosa‐Neto, Pedro , Lussier, Firoza Z. , Therriault, Joseph , Soucy, Jean‐Paul

in Activities of daily living / Aging / Alzheimer's disease / amyloid beta / Biomarkers / Clinical trials / Cognitive ability / Dementia / Magnetic resonance imaging / Observational studies / positron emission tomography / Statistical analysis / Tomography / Young adults

2023

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Amyloid beta plaque accumulation with longitudinal 18FAZD4694 PET

2023

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2023

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Journal Article

Amyloid beta plaque accumulation with longitudinal 18FAZD4694 PET

Vitali, Paolo,

Fernandez‐Arias, Jaime,

Massarweh, Gassan,

Stevenson, Jenna,

Vermeiren, Marie,

Tissot, Cécile,

Servaes, Stijn,

Pascoal, Tharick A.,

Pallen, Vanessa,

Chamoun, Mira,

Saha‐Chaudhuri, Paramita,

Wang, Yi‐Ting,

Rahmouni, Nesrine,

Kunach, Peter,

Bezgin, Gleb,

Gauthie, Serge,

Rosa‐Neto, Pedro,

Lussier, Firoza Z.,

Therriault, Joseph,

Soucy, Jean‐Paul

2023

Overview

[18F]AZD4694 is an amyloid beta (Aβ) imaging agent used in several observational studies and clinical trials. However, no studies have yet published data on longitudinal Aβ accumulation measured with [18F]AZD4694. We assessed 146 individuals who were evaluated with [18F]AZD4694 at baseline and 2-year follow-up. We calculated annual rates of [18F]AZD4694 change for clinically defined and biomarker-defined groups. Cognitively unimpaired (CU) older adults displayed subtle [18F]AZD4694 standardized uptake value ratio (SUVR) accumulation over the follow-up period. In contrast, Aβ positive CU older adults displayed higher annual [18F]AZD4694 SUVR increases. [18F]AZD4694 SUVR accumulation in Aβ positive mild cognitive impairment (MCI) and dementia was modest across the neocortex. Larger increases in [18F]AZD4694 SUVR were observed in CU individuals who had abnormal amyloid positron emission tomography levels at baseline. [18F]AZD4694 can be used to monitor Aβ levels in therapeutic trials as well as clinical settings, particularly prior to initiating anti-amyloid therapies.

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Publisher

John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley

Subject

Activities of daily living

/ Aging

/ Alzheimer's disease