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Hyperpolarized water through dissolution dynamic nuclear polarization with UV-generated radicals
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Journal Article
Hyperpolarized water through dissolution dynamic nuclear polarization with UV-generated radicals
2020
Overview
In recent years, hyperpolarization of water protons via dissolution Dynamic Nuclear Polarization (dDNP) has attracted increasing interest in the magnetic resonance community. Hyperpolarized water may provide an alternative to Gd-based contrast agents for angiographic and perfusion Magnetic Resonance Imaging (MRI) examinations, and it may report on chemical and biochemical reactions and proton exchange while perfoming Nuclear Magnetic Resonance (NMR) investigations. However, hyperpolarizing water protons is challenging. The main reason is the presence of radicals, required to create the hyperpolarized nuclear spin state. Indeed, the radicals will also be the main source of relaxation during the dissolution and transfer to the NMR or MRI system. In this work, we report water magnetizations otherwise requiring a field of 10,000 T at room temperature on a sample of pure water, by employing dDNP via UV-generated, labile radicals. We demonstrate the potential of our methodology by acquiring a
15
N spectrum from natural abundance urea with a single scan, after spontaneous magnetization transfer from water protons to nitrogen nuclei.
Hyperpolarised water is an attractive alternative to metal-containing contrast agents in magnetic resonance imaging, but generating usefully persistent hyperpolarised water protons is challenging. Here dissolution dynamic nuclear polarisation using UV-generated radicals is used to obtain substantial water signal enhancement.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
