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H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo
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H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo
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H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo
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Journal Article
H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo
2020
Overview
Afterglow luminescent probes with high signal-to-background ratio show promise for in vivo imaging; however, such probes that can be selectively delivered into target sites and switch on afterglow luminescence remain limited. We optimize an organic electrochromic material and integrate it into near-infrared (NIR) photosensitizer (silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) and (poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene]) containing nanoparticles, developing an H
2
S-activatable NIR afterglow probe (
F1
2+
-ANP).
F1
2+
-ANP displays a fast reaction rate (1563 ± 141 M
−1
s
−1
) and large afterglow turn-on ratio (~122-fold) toward H
2
S, enabling high-sensitivity and -specificity measurement of H
2
S concentration in bloods from healthy persons, hepatic or colorectal cancer patients. We further construct a hepatic-tumor-targeting and H
2
S-activatable afterglow probe (
F1
2+
-ANP-Gal) for noninvasive, real-time imaging of tiny subcutaneous HepG2 tumors (<3 mm in diameter) and orthotopic liver tumors in mice. Strikingly,
F1
2+
-ANP-Gal accurately delineates tumor margins in excised hepatic cancer specimens, which may facilitate intraoperative guidance of hepatic cancer surgery.
Afterglow imaging probes are of interest for in vivo imaging due to high signal-to-background ratios. Here, the authors report on an afterglow nanoparticle which is activated by hydrogen sulphide and demonstrate the measurement of hydrogen sulphide levels and the labelling of hepatic cancer specimens in vivo.
