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Personalized cancer vaccines: adjuvants are important, too
by
Gouttefangeas, Cécile
, Rammensee, Hans-Georg
in
Adjuvants
/ Antigens
/ Cancer vaccines
/ Immunization
/ Immunogenicity
/ Immunology
/ Immunosuppression
/ Immunotherapy
/ Leukemia
/ Ligands
/ Lymphocytes
/ Medical research
/ Melanoma
/ Mutation
/ Patients
/ Peptides
/ Proteins
/ T cell receptors
/ Tumors
/ Vaccines
2018
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Personalized cancer vaccines: adjuvants are important, too
by
Gouttefangeas, Cécile
, Rammensee, Hans-Georg
in
Adjuvants
/ Antigens
/ Cancer vaccines
/ Immunization
/ Immunogenicity
/ Immunology
/ Immunosuppression
/ Immunotherapy
/ Leukemia
/ Ligands
/ Lymphocytes
/ Medical research
/ Melanoma
/ Mutation
/ Patients
/ Peptides
/ Proteins
/ T cell receptors
/ Tumors
/ Vaccines
2018
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Do you wish to request the book?
Personalized cancer vaccines: adjuvants are important, too
by
Gouttefangeas, Cécile
, Rammensee, Hans-Georg
in
Adjuvants
/ Antigens
/ Cancer vaccines
/ Immunization
/ Immunogenicity
/ Immunology
/ Immunosuppression
/ Immunotherapy
/ Leukemia
/ Ligands
/ Lymphocytes
/ Medical research
/ Melanoma
/ Mutation
/ Patients
/ Peptides
/ Proteins
/ T cell receptors
/ Tumors
/ Vaccines
2018
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Personalized cancer vaccines: adjuvants are important, too
Journal Article
Personalized cancer vaccines: adjuvants are important, too
2018
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Overview
Therapeutic cancer vaccines have shown limited clinical efficacy so far. Nevertheless, in the meantime, our understanding of immune cell function and the interactions of immune cells with growing tumors has advanced considerably. We are now in a position to invest this knowledge into the design of more powerful vaccines and therapy combinations aimed at increasing immunogenicity and decreasing tumor-induced immunosuppression. This review focuses essentially on peptide-based human vaccines. We will discuss two aspects that are critical for increasing their intrinsic immunogenicity: the selection of the antigen(s) to be targeted, and the as yet unmet need for strong adjuvants.
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