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Natural Antispasmodics: Source, Stereochemical Configuration, and Biological Activity

by Hernández, Luis R. , Juárez, Zaida N. , Martínez-Pérez, Edith Fabiola , Bach, Horacio

in Alkaloids / Animals / Asteraceae - chemistry / Biological activity / Biomedical research / Chlormezanone / Enzymes / Flavonoids / Glutethimide / Histamine / Humans / Hyoscyamine / Illnesses / Kinases / Lamiaceae - chemistry / Model testing / Monoterpenoids / Muscle relaxants / Mutation / Narcotics / Natural products / Neurons / Neurotransmitters / Organic chemistry / Parasympathetic nervous system / Parasympatholytics - chemistry / Parasympatholytics - isolation & purification / Parasympatholytics - therapeutic use / Pharmacology / Physiology / Proteins / Review / Saponins / Smooth muscle / Structure-Activity Relationship / Terrestrial environments / Traditional medicine / Triterpenes / Tubocurarine

2018

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Natural Antispasmodics: Source, Stereochemical Configuration, and Biological Activity

by Hernández, Luis R. , Juárez, Zaida N. , Martínez-Pérez, Edith Fabiola , Bach, Horacio

2018

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Natural Antispasmodics: Source, Stereochemical Configuration, and Biological Activity

by Hernández, Luis R. , Juárez, Zaida N. , Martínez-Pérez, Edith Fabiola , Bach, Horacio

2018

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Journal Article

Natural Antispasmodics: Source, Stereochemical Configuration, and Biological Activity

Hernández, Luis R.,

Juárez, Zaida N.,

Martínez-Pérez, Edith Fabiola,

Bach, Horacio

2018

Overview

Natural products with antispasmodic activity have been used in traditional medicine to alleviate different illnesses since the remote past. We searched the literature and compiled the antispasmodic activity of 248 natural compounds isolated from terrestrial plants. In this review, we summarized all the natural products reported with antispasmodic activity until the end of 2017. We also provided chemical information about their extraction as well as the model used to test their activities. Results showed that members of the Lamiaceae and Asteraceae families had the highest number of isolated compounds with antispasmodic activity. Moreover, monoterpenoids, flavonoids, triterpenes, and alkaloids were the chemical groups with the highest number of antispasmodic compounds. Lastly, a structural comparison of natural versus synthetic compounds was discussed.

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Publisher

Hindawi Publishing Corporation,Hindawi,John Wiley & Sons, Inc

Subject

Alkaloids

/ Animals

/ Asteraceae - chemistry

/ Biological activity

/ Biomedical research

/ Chlormezanone

/ Enzymes