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Space flight associated changes in astronauts’ plasma‐derived small extracellular vesicle microRNA: Biomarker identification
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Space flight associated changes in astronauts’ plasma‐derived small extracellular vesicle microRNA: Biomarker identification
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Journal Article
Space flight associated changes in astronauts’ plasma‐derived small extracellular vesicle microRNA: Biomarker identification
2022
Overview
Of note, sRNAseq was performed using RNA isolated from sEVs of 14 astronauts, while qPCR analysis could only be performed on seven astronauts due to the exceptionally rare sample availability. [...]out of an abundance of caution, we narrowed our focus to hsa-miR-4732-3p, which displayed significant regulation at R+3 compared to L-10 by qPCR. [...]we extended our analysis to determine potential diseases that hsa-miR-4732-3p may be involved. [...]our data suggest that short LEO spaceflight induced significant changes in plasma-derived sEV miRNA content and identified hsa-miR-4732-3p to be significantly upregulated post-flight.
Publisher
John Wiley & Sons, Inc,Springer,John Wiley and Sons Inc,Wiley
