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The “in and out” of glucosamine 6-O-sulfation: the 6th sense of heparan sulfate
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The “in and out” of glucosamine 6-O-sulfation: the 6th sense of heparan sulfate
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Journal Article
The “in and out” of glucosamine 6-O-sulfation: the 6th sense of heparan sulfate
2017
Overview
The biological properties of Heparan sulfate (HS) polysaccharides essentially rely on their ability to bind and modulate a multitude of protein ligands. These interactions involve internal oligosaccharide sequences defined by their sulfation patterns. Amongst these, the 6-
O
-sulfation of HS contributes significantly to the polysaccharide structural diversity and is critically involved in the binding of many proteins. HS 6-
O
-sulfation is catalyzed by 6-
O
-sulfotransferases (6OSTs) during biosynthesis, and it is further modified by the post-synthetic action of 6-
O
-endosulfatases (Sulfs), two enzyme families that remain poorly characterized. The aim of the present review is to summarize the contribution of 6-
O
-sulfates in HS structure/function relationships and to discuss the present knowledge on the complex mechanisms regulating HS 6-
O
-sulfation.
Publisher
Springer US,Springer Nature B.V,Springer Verlag
Subject
/ Animals
/ Biochemistry, Molecular Biology
/ Biology
/ Biomedical and Life Sciences
/ Cancer
/ Glucosamine - analogs & derivatives
/ Heparitin Sulfate - chemistry
/ Heparitin Sulfate - metabolism
/ Humans
/ Intercellular Signaling Peptides and Proteins - chemistry
/ Intercellular Signaling Peptides and Proteins - metabolism
/ Ligands
/ Nerve Tissue Proteins - chemistry
/ Nerve Tissue Proteins - metabolism
/ Proteins
/ Review
/ Reviews
/ Structure-Activity Relationship
/ Structure-function relationships
/ Sulfotransferases - chemistry
/ Sulfotransferases - metabolism
