Asset Details
Do you wish to reserve the book?
Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance
Do you wish to request the book?
Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance
2013
Overview
Aims/hypothesis
Insulin clearance is a highly heritable trait, for which few quantitative trait loci have been discovered. We sought to determine whether validated type 2 diabetes and/or glycaemic trait loci are associated with insulin clearance.
Methods
Hyperinsulinaemic–euglycaemic clamps were performed in two Hispanic-American family cohorts totalling 1329 participants in 329 families. The Metabochip was used to fine-map about 50 previously identified loci for type 2 diabetes, fasting glucose, fasting insulin, 2 h glucose or HbA
1c
. This resulted in 17,930 variants, which were tested for association with clamp-derived insulin clearance via meta-analysis of the two cohorts.
Results
In the meta-analysis, 38 variants located within seven loci demonstrated association with insulin clearance (
p
< 0.001). The top signals for each locus were rs10241087 (
DGKB/TMEM195
[
TMEM195
also known as
AGMO
]) (
p
= 4.4 × 10
−5
); chr1:217605433 (
LYPLAL1
) (
p
= 3.25 × 10
−4
); rs2380949 (
GLIS3
) (
p
= 3.4 × 10
−4
); rs55903902 (
FADS1
) (
p
= 5.6 × 10
−4
); rs849334 (
JAZF1
) (
p
= 6.4 × 10
−4
); rs35749 (
IGF1
) (
p
= 6.7 × 10
−4
); and rs9460557 (
CDKAL1
) (
p
= 6.8 × 10
−4
).
Conclusions/interpretation
While the majority of validated loci for type 2 diabetes and related traits do not appear to influence insulin clearance in Hispanics, several of these loci do show evidence of association with this trait. It is therefore possible that these loci could have pleiotropic effects on insulin secretion, insulin sensitivity and insulin clearance.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
Subject
/ Biological and medical sciences
/ Delta-5 Fatty Acid Desaturase
/ Diabetes
/ Diabetes Mellitus, Type 2 - blood
/ Diabetes Mellitus, Type 2 - diagnosis
/ Diabetes Mellitus, Type 2 - genetics
/ Diabetes. Impaired glucose tolerance
/ Endocrine pancreas. Apud cells (diseases)
/ Etiopathogenesis. Screening. Investigations. Target tissue resistance
/ Female
/ Genomes
/ Glucose
/ Glycated Hemoglobin - chemistry
/ Humans
/ Insulin Resistance - genetics
/ Male
/ Medicine
