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Colony-Stimulating Factors for Febrile Neutropenia during Cancer Therapy
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Journal Article
Colony-Stimulating Factors for Febrile Neutropenia during Cancer Therapy
2013
Overview
A woman receives a diagnosis of diffuse large B-cell lymphoma; a standard chemotherapy regimen is recommended. Use of prophylactic granulocyte CSF is considered. G-CSF stimulates proliferation of neutrophil progenitors and release of mature neutrophils from bone marrow.
Foreword
This
Journal
feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the authors' clinical recommendations.
Stage
A 55-year-old, previously healthy woman received a diagnosis of diffuse large-B-cell lymphoma after the evaluation of an enlarged left axillary lymph node obtained on biopsy. She had been asymptomatic except for the presence of enlarged axillary lymph nodes, which she had found while bathing. She was referred to an oncologist, who performed a staging evaluation. A complete blood count and test results for liver and renal function and serum lactate dehydrogenase were normal. Positron-emission tomography and computed tomography (PET–CT) identified enlarged lymph nodes with abnormal uptake in the left axilla, mediastinum, and retroperitoneum. Results on bone marrow biopsy were . . .
Publisher
Massachusetts Medical Society
Subject
/ Antineoplastic Combined Chemotherapy Protocols - adverse effects
/ Biological and medical sciences
/ Cancer
/ Female
/ Granulocyte colony-stimulating factor
/ Granulocyte Colony-Stimulating Factor - adverse effects
/ Granulocyte Colony-Stimulating Factor - therapeutic use
/ Hematologic and hematopoietic diseases
/ Humans
/ Lymphoma, Large B-Cell, Diffuse - drug therapy
/ Neutropenia - chemically induced
/ Neutropenia - prevention & control
/ Other diseases. Hematologic involvement in other diseases
/ Patients
/ Practice Guidelines as Topic
