Asset Details
Do you wish to reserve the book?
Increased CD4 and CD8-positive T cell infiltrate signifies good prognosis in a subset of triple-negative breast cancer
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Increased CD4 and CD8-positive T cell infiltrate signifies good prognosis in a subset of triple-negative breast cancer
Do you wish to request the book?
Increased CD4 and CD8-positive T cell infiltrate signifies good prognosis in a subset of triple-negative breast cancer
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Increased CD4 and CD8-positive T cell infiltrate signifies good prognosis in a subset of triple-negative breast cancer
2016
Overview
Tumour-infiltrating lymphocytes (TILs) signify immune response to tumour in a variety of cancers including breast cancer. However, earlier studies examining the clinical significance of TILs in breast cancers have generated mixed results. There are only a few that address the relationship between TILs and clinical outcomes in triple-negative breast cancers (TNBC). The aim of this study is to evaluate the clinical significance of TILs that express CD4 + and CD8 + , in TNBC. Immunohistochemical staining of CD4 and CD8 was performed on tissue microarrays of 164 cases of TNBC. TILs were counted separately as intratumoral when within the cancer cell nests (iTILs) and as stromal when within cancer stroma (sTILs). High CD8 + iTILs and sTILs, and CD4 + iTILs correlated with histologic grade. On Kaplan–Meier analysis, a significantly better survival rate was observed in high CD8 + iTIL (disease-free survival, DFS:
P
= 0.004, overall survival, OS:
P
= 0.02) and both high CD4 + iTILs (DFS:
P
= 0.025, OS:
P
= 0.023) and sTILs (DFS:
P
= 0.01, OS:
P
= 0.002). In multivariate analysis, CD8 + iTILs (DFS:
P
= 0.0095), CD4 + sTILs (DFS:
P
= 0.0084; OS:
P
= 0.0118), and CD4
high
CD8
high
CD8 iTILs (DFS:
P
= 0.0121; OS:
P
= 0.0329) and sTILs (DFS:
P
= 0.0295) showed significantly better survival outcomes. These results suggest that high levels of both CD8 + iTILs and CD4 + sTILs as well as CD4
high
CD8
high
iTILs and sTILs are independent prognostic factors in TNBC.
Publisher
Springer US,Springer,Springer Nature B.V
Subject
/ Aged
/ Analysis
/ Biomarkers, Tumor - immunology
/ CD4-Positive T-Lymphocytes - immunology
/ CD4-Positive T-Lymphocytes - pathology
/ CD8-Positive T-Lymphocytes - immunology
/ CD8-Positive T-Lymphocytes - pathology
/ Female
/ Humans
/ Lymphocytes, Tumor-Infiltrating - immunology
/ Lymphocytes, Tumor-Infiltrating - pathology
/ Medicine
/ Oncology
/ T cells
/ Triple Negative Breast Neoplasms - immunology
/ Triple Negative Breast Neoplasms - pathology
/ Tumors
