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Ubiquitin signaling in immune responses
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Journal Article
Ubiquitin signaling in immune responses
2016
Overview
Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in diverse biological pro- cesses, including different aspects of immune functions. Ubiquitination regulates pattern-recognition receptor sig- naling that mediates both innate immune responses and dendritic cell maturation required for initiation of adaptive immune responses. Ubiquitination also regulates the development, activation, and differentiation of T cells, thereby maintaining efficient adaptive immune responses to pathogens and immunological tolerance to self-tissues. Like phosphorylation, ubiquitination is a reversible reaction tightly controlled by the opposing actions of ubiquitin ligases and deubiquitinases. Deregulated ubiquitination events are associated with immunological disorders, including auto- immune and inflammatory diseases.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
