Journal Article

Respiratory and Peripheral Muscle Weakness and Body Composition Abnormalities in Non-Cystic Fibrosis Bronchiectasis Patients: Gender Differences

Barreiro, Esther, Wang, Xuejie, Martínez-Llorens, Juana, Qin, Liyun, Xia, Yingchen, Balaña-Corberó, Ana, Zha, Jianhua, Maiques, José María

2022

Overview

As demonstrated in COPD, bronchiectasis patients may experience respiratory and peripheral muscle dysfunction. We hypothesized that respiratory and peripheral (upper and lower limbs) muscle function and nutritional status may be more significantly altered in female than in males for identical age and disease severity. In mild-to-moderate bronchiectasis patients ( = 150, 114 females) and 37 controls ( = 37, 21 females), radiological extension, maximal inspiratory and expiratory pressures (MIP and MEP), sniff nasal inspiratory pressure (SNIP), hand grip and quadriceps muscle strengths, body composition, and blood analytical biomarkers were explored. Compared to the controls, in all bronchiectasis patients (males and females), BMI, fat-free mass index (FFMI), fat tissue, upper and lower limb muscle strength, and respiratory muscle strength significantly declined, and FFMI, fat tissue, and quadriceps muscle function were significantly lower in female than male patients. In patients with mild-to-moderate bronchiectasis, respiratory and peripheral muscle function is significantly impaired and only partly related to lung disease status. Quadriceps muscle strength was particularly weakened in the female patients and was negatively associated with their exercise tolerance. Muscle weakness should be therapeutically targeted in bronchiectasis patients. Body composition and peripheral muscle function determination should be part of the comprehensive clinical assessment of these patients.

• Publisher: MDPI AG,MDPI
• Subject: Airway management / Biomarkers / Body composition / Bronchiectasis / bronchiectasis patients / Cardiovascular disease / Chronic obstructive pulmonary disease / COVID-19 / Cystic fibrosis / differences between male and female patients / Emphysema / Exercise / Fat-free body mass / Females / Gender differences / lower limb muscle function / Lung diseases / Muscle function / Muscle strength / muscle weakness / Musculoskeletal system / Nutritional status / Patients / Physical fitness / Pulmonary arteries / Quadriceps muscle / Respiration / Respiratory diseases / respiratory muscle function / Sarcopenia / Sex differences / upper limb muscle function / Values