Asset Details
Do you wish to reserve the book?
Clinical Insights Into Default Mode Network Abnormalities in Mild Traumatic Brain Injury: Unraveling Axonal Injury Through Functional, Structural, and Molecular Analyses
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Clinical Insights Into Default Mode Network Abnormalities in Mild Traumatic Brain Injury: Unraveling Axonal Injury Through Functional, Structural, and Molecular Analyses
Do you wish to request the book?
Clinical Insights Into Default Mode Network Abnormalities in Mild Traumatic Brain Injury: Unraveling Axonal Injury Through Functional, Structural, and Molecular Analyses
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Clinical Insights Into Default Mode Network Abnormalities in Mild Traumatic Brain Injury: Unraveling Axonal Injury Through Functional, Structural, and Molecular Analyses
2024
Overview
Background Mild traumatic brain injury (mTBI) frequently results in persistent cognitive, emotional, and functional impairments, closely linked to disruptions in the default mode network (DMN). Understanding the mechanisms driving these network abnormalities is critical for advancing diagnostic and therapeutic strategies. Methods This study adopted a multimodal approach, combining functional connectivity (FC) analysis, diffusion tensor imaging (DTI), and gene expression profiling to investigate DMN disruptions in mTBI. A primary focus was placed on the middle cingulate cortex (MCC), a region consistently identified with increased connectivity. We explored the structural and molecular changes underlying this phenomenon. Receiver operating characteristic (ROC) curve analysis was utilized to assess the diagnostic potential of DTI‐derived metrics, while white matter tractography was employed to explore structural connectivity between the MCC and the dorsolateral prefrontal cortex (DLPFC). Results Our findings revealed significant disruptions in DMN connectivity, with the MCC prominently involved in mTBI pathology. DTI analyses identified pronounced axonal injury in the MCC, characterized by decreased fractional anisotropy (FA) and axial diffusivity (AD), alongside increased isotropy (ISO), indicating compromised white matter integrity and diffuse axonal injury. Gene expression profiling revealed the upregulation of pathways related to synaptic transmission, ion channel regulation, and axonal injury response. ROC analysis demonstrated that ISO serves as a particularly effective biomarker for mTBI, showing high diagnostic accuracy (AUC = 0.871). White matter tractography further confirmed strong structural connectivity between the MCC and the DLPFC, identifying potential therapeutic targets for neuromodulation. Conclusion This study provides robust evidence that diffuse axonal injury plays a pivotal role in DMN abnormalities observed in mTBI. The integration of FC, DTI, and gene expression profiling offers a comprehensive framework for understanding mTBI's impact on brain networks. Our findings also highlight the DLPFC as a promising target for therapeutic interventions aimed at addressing cognitive and emotional deficits associated with mTBI. This study explores the relationship between mild traumatic brain injury (mTBI) and disruptions in the default mode network (DMN) using a multimodal approach. Through functional connectivity analysis, diffusion tensor imaging, and gene expression profiling, the research highlights the role of diffuse axonal injury in DMN abnormalities, particularly in the middle cingulate cortex (MCC). The study suggests potential therapeutic targets for neuromodulation, such as the dorsolateral prefrontal cortex (DLPFC), to mitigate cognitive and emotional disturbances associated with mTBI.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc
Subject
/ Brain Concussion - diagnostic imaging
/ Brain Concussion - pathology
/ Brain Concussion - physiopathology
/ Default Mode Network - diagnostic imaging
/ Default Mode Network - pathology
/ Diffuse Axonal Injury - diagnostic imaging
/ Diffuse Axonal Injury - pathology
/ Diffusion Tensor Imaging - methods
/ Emotions
/ Female
/ Functional magnetic resonance imaging
/ Gyrus Cinguli - diagnostic imaging
/ Gyrus Cinguli - physiopathology
/ Humans
/ Male
/ Original
/ Structure-function relationships
