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Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration

by Li, Sheng , Wang, Jianhua , Shao, Xiexiang , Wang, Minghui , Fu, Xin , Yang, Wenjun , Zhou, Hao , Lin, Xingzuan , Zhou, Shenao , Li, Zhanghua , Hu, Ping , Han, Lili , Zhu, Siyuan

in Analysis / Animals / CD56 Antigen - analysis / CD56 Antigen - metabolism / Cell Differentiation / Humans / Integrin beta1 - analysis / Integrin beta1 - metabolism / Mice / Muscle Development / myogenic progenitors / Regeneration / Stem cells / Stem Cells - physiology / Stem Cells and Regenerative Medicine / Tendon Injuries - therapy / tendon injury / tendon regeneration / Tendons - physiology / Transforming growth factors

2025

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Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration

by Li, Sheng , Wang, Jianhua , Shao, Xiexiang , Wang, Minghui , Fu, Xin , Yang, Wenjun , Zhou, Hao , Lin, Xingzuan , Zhou, Shenao , Li, Zhanghua , Hu, Ping , Han, Lili , Zhu, Siyuan

2025

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Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration

by Li, Sheng , Wang, Jianhua , Shao, Xiexiang , Wang, Minghui , Fu, Xin , Yang, Wenjun , Zhou, Hao , Lin, Xingzuan , Zhou, Shenao , Li, Zhanghua , Hu, Ping , Han, Lili , Zhu, Siyuan

2025

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Journal Article

Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration

Li, Sheng,

Wang, Jianhua,

Shao, Xiexiang,

Wang, Minghui,

Fu, Xin,

Yang, Wenjun,

Zhou, Hao,

Lin, Xingzuan,

Zhou, Shenao,

Li, Zhanghua,

Hu, Ping,

Han, Lili,

Zhu, Siyuan

2025

Overview

Tendon injury occurs at high frequency and is difficult to repair. Identification of human stem cells being able to regenerate tendon will greatly facilitate the development of regenerative medicine for tendon injury. Genetic and functional analyses identify human CD29+/CD56+ myogenic progenitors with tenogenic differentiation potential in vitro and in vivo. Transplantation of human CD29+/CD56+ myogenic progenitors contributes to injured tendon repair and thus improves locomotor function. Interestingly, the tendon differentiation potential in mouse muscle stem cells is minimal and the higher TGFβ signaling level may be the key for the distinct feature of human CD29+/CD56+ myogenic progenitors. The discovery of bi-potential CD29+/CD56+ myogenic progenitors highlights their potential as a novel adult stem cell source for tendon regeneration.

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Publisher

eLife Science Publications, Ltd,eLife Sciences Publications, Ltd,eLife Sciences Publications Ltd

Subject

Analysis

/ Animals

/ CD56 Antigen - analysis

/ CD56 Antigen - metabolism

/ Cell Differentiation

/ Humans

/ Integrin beta1 - analysis