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Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
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Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
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Journal Article
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
2007
Overview
Imaging of collectively invading cocultures of carcinoma cells and stromal fibroblasts reveals that the leading cell is always a fibroblast and that carcinoma cells move within tracks in the extracellular matrix behind the fibroblast. The generation of these tracks by fibroblasts is sufficient to enable the collective invasion of the squamous cell carcinoma (SCC) cells and requires both protease- and force-mediated matrix remodelling. Force-mediated matrix remodelling depends on integrins α3 and α5, and Rho-mediated regulation of myosin light chain (MLC) activity in fibroblasts, but these factors are not required in carcinoma cells. Instead, carcinoma cells use Cdc42 and MRCK (myotonic dystrophy kinase-related CDC42-binding protein kinases) mediated regulation of MLC to follow the tracks generated by fibroblasts.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Biology
/ Biomedical and Life Sciences
/ Carcinoma, Squamous Cell - metabolism
/ Carcinoma, Squamous Cell - pathology
/ Carcinoma, Squamous Cell - ultrastructure
/ cdc42 GTP-Binding Protein - physiology
/ Extracellular Matrix - metabolism
/ Extracellular Matrix - ultrastructure
/ Heat-Shock Proteins - physiology
/ Humans
/ Integrin alpha3 - metabolism
/ Integrin alpha5 - metabolism
/ Kinases
/ Motility
/ Myosin Light Chains - metabolism
