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Endothelial‐Derived Extracellular Vesicles During Exercise in COPD Patients
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Endothelial‐Derived Extracellular Vesicles During Exercise in COPD Patients
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Journal Article
Endothelial‐Derived Extracellular Vesicles During Exercise in COPD Patients
2025
Overview
Introduction There are no treatments directly targeting the pulmonary vasculature in chronic obstructive pulmonary disease (COPD), and further characterization of the underlying endothelial cell (EC) abnormalities could be helpful in drug development. Methods We investigated the influence of exercise and the prostacyclin analog iloprost on extracellular vesicles derived from ECs (eEVs) in 15 moderate–severe COPD patients who were enrolled in a randomized, placebo‐controlled crossover trial of iloprost. Results Active smokers had a profile consistent with inflammatory‐derived EVs, while exacerbation‐prone COPD subjects had a profile consistent with apoptosis‐derived eEVs. There were no significant effects of iloprost on eEV levels. However, there was a significant increase in CD144+ and CD31+/CD144+ EVs 1 h after exercise. Conclusions Endothelial‐derived EV profiles differed based on smoking and exacerbation history. Iloprost did not affect eEV levels, although maximal exercise induced a delayed increase in a subset of eEVs, possibly through shear stress. In this secondary analysis of a placebo‐controlled crossover trial enrolling COPD patients, there was no difference in exercise‐induced changes of endothelial‐derived extracellular vesicles (eEVs) between iloprost and placebo. The eEV profile was different based on smoking and exacerbation history. Compared to baseline values, eEV levels increased 1 h after maximal exercise.
Publisher
John Wiley & Sons, Inc,Wiley
Subject
/ Chronic obstructive pulmonary disease
/ Endothelial Cells - drug effects
/ Endothelial Cells - metabolism
/ Extracellular Vesicles - drug effects
/ Extracellular Vesicles - metabolism
/ Female
/ Humans
/ Iloprost - administration & dosage
/ Male
/ Patients
/ Pulmonary Disease, Chronic Obstructive - drug therapy
/ Pulmonary Disease, Chronic Obstructive - metabolism
