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Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutralized by diabetes-associated specific antibodies
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Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutralized by diabetes-associated specific antibodies
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Journal Article
Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutralized by diabetes-associated specific antibodies
2014
Overview
Soluble oligomeric assemblies of amyloidal proteins appear to act as major pathological agents in several degenerative disorders. Isolation and characterization of these oligomers is a pivotal step towards determination of their pathological relevance. Here we describe the isolation of Type 2 diabetes-associated islet amyloid polypeptide soluble cytotoxic oligomers; these oligomers induced apoptosis in cultured pancreatic cells, permeated model lipid vesicles and interacted with cell membranes following complete internalization. Moreover, antibodies which specifically recognized these assemblies, but not monomers or amyloid fibrils, were exclusively identified in diabetic patients and were shown to neutralize the apoptotic effect induced by these oligomers. Our findings support the notion that human IAPP peptide can form highly toxic oligomers. The presence of antibodies identified in the serum of diabetic patients confirms the pathological relevance of the oligomers. In addition, the newly identified structural epitopes may also provide new mechanistic insights and a molecular target for future therapy.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/1
/ 13/31
/ 14/19
/ 631/1647
/ 631/45
/ 82/16
/ Amylin
/ Antibodies, Neutralizing - immunology
/ Antibodies, Neutralizing - pharmacology
/ Autoantibodies - pharmacology
/ Cell Membrane Permeability - drug effects
/ Diabetes
/ Diabetes Mellitus, Type 2 - immunology
/ Diabetes Mellitus, Type 2 - metabolism
/ Epitopes
/ Fibrils
/ Humanities and Social Sciences
/ Humans
/ Insulin-Secreting Cells - drug effects
/ Insulin-Secreting Cells - metabolism
/ Islet Amyloid Polypeptide - chemistry
/ Islet Amyloid Polypeptide - immunology
/ Islet Amyloid Polypeptide - pharmacology
/ Monomers
/ Pancreas
/ Protein Structure, Secondary
/ Science
