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The putative Na+/Cl−-dependent neurotransmitter/osmolyte transporter inebriated in the Drosophila hindgut is essential for the maintenance of systemic water homeostasis
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The putative Na+/Cl−-dependent neurotransmitter/osmolyte transporter inebriated in the Drosophila hindgut is essential for the maintenance of systemic water homeostasis
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The putative Na+/Cl−-dependent neurotransmitter/osmolyte transporter inebriated in the Drosophila hindgut is essential for the maintenance of systemic water homeostasis
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Journal Article
The putative Na+/Cl−-dependent neurotransmitter/osmolyte transporter inebriated in the Drosophila hindgut is essential for the maintenance of systemic water homeostasis
2015
Overview
Most organisms are able to maintain systemic water homeostasis over a wide range of external or dietary osmolarities. The excretory system, composed of the kidneys in mammals and the Malpighian tubules and hindgut in insects, can increase water conservation and absorption to maintain systemic water homeostasis, which enables organisms to tolerate external hypertonicity or desiccation. However, the mechanisms underlying the maintenance of systemic water homeostasis by the excretory system have not been fully characterized. In the present study, we found that the putative Na
+
/Cl
−
-dependent neurotransmitter/osmolyte transporter inebriated (ine) is expressed in the basolateral membrane of anterior hindgut epithelial cells. This was confirmed by comparison with a known basolateral localized protein, the α subunit of Na
+
-K
+
ATPase (ATPα). Under external hypertonicity, loss of ine in the hindgut epithelium results in severe dehydration without damage to the hindgut epithelial cells, implicating a physiological failure of water conservation/absorption. We also found that hindgut expression of ine is required for water conservation under desiccating conditions. Importantly, specific expression of ine in the hindgut epithelium can completely restore disrupted systemic water homeostasis in
ine
mutants under both conditions. Therefore, ine in the
Drosophila
hindgut is essential for the maintenance of systemic water homeostasis.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 14/19
/ 64/24
/ Animals
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ Hindgut
/ Humanities and Social Sciences
/ Insects
/ Intestinal Mucosa - metabolism
/ Neurotransmitter Transport Proteins - genetics
/ Neurotransmitter Transport Proteins - metabolism
/ Plasma Membrane Neurotransmitter Transport Proteins - genetics
/ Plasma Membrane Neurotransmitter Transport Proteins - metabolism
/ Science
/ Sodium
