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Activation of Vago by interferon regulatory factor (IRF) suggests an interferon system-like antiviral mechanism in shrimp
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Activation of Vago by interferon regulatory factor (IRF) suggests an interferon system-like antiviral mechanism in shrimp
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Journal Article
Activation of Vago by interferon regulatory factor (IRF) suggests an interferon system-like antiviral mechanism in shrimp
2015
Overview
There is a debate on whether invertebrates possess an antiviral immunity similar to the interferon (IFN) system of vertebrates. The Vago gene from arthropods encodes a viral-activated secreted peptide that restricts virus infection through activating the JAK-STAT pathway and is considered to be a cytokine functionally similar to IFN. In this study, the first crustacean IFN regulatory factor (IRF)-like gene was identified in Pacific white shrimp,
Litopenaeus vannamei
. The
L. vannamei
IRF showed similar protein nature to mammalian IRFs and could be activated during virus infection. As a transcriptional regulatory factor,
L. vannamei
IRF could activate the IFN-stimulated response element (ISRE)-containing promoter to regulate the expression of mammalian type I IFNs and initiate an antiviral state in mammalian cells. More importantly, IRF could bind the 5′-untranslated region of
L. vannamei
Vago4 gene and activate its transcription, suggesting that shrimp Vago may be induced in a similar manner to that of IFNs and supporting the opinion that Vago might function as an IFN-like molecule in invertebrates. These suggested that shrimp might possess an IRF-Vago-JAK/STAT regulatory axis, which is similar to the IRF-IFN-JAK/STAT axis of vertebrates, indicating that invertebrates might possess an IFN system-like antiviral mechanism.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/109
/ 13/89
/ 13/95
/ 14/19
/ 38/39
/ 38/77
/ 38/90
/ 45/29
/ 82/80
/ Animals
/ Computational Biology - methods
/ Humanities and Social Sciences
/ Interferon regulatory factor
/ Interferon Regulatory Factors - chemistry
/ Interferon Regulatory Factors - genetics
/ Interferon Regulatory Factors - metabolism
/ Mammals
/ Science
