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Trends in brain-dead organ donor characteristics: a 13-year analysis
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Trends in brain-dead organ donor characteristics: a 13-year analysis
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Trends in brain-dead organ donor characteristics: a 13-year analysis
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Journal Article
Trends in brain-dead organ donor characteristics: a 13-year analysis
2016
Overview
Driven by disease trends, such as obesity and metabolic syndrome, that are increasingly prevalent in the general population, we aimed to evaluate the comorbidities and attributes of the brain-dead organ donor population over time in a longitudinal study.
We compared overall health and baseline attributes of organ donors between 2000–2005 and 2006–2012 using our prospective transplant database. Descriptive and comparative analyses of the 2 historical cohorts were performed.
A total of 1040 brain-dead organ donors were included in our analysis: 496 from the 2000–2005 period and 544 from the 2006–2012 period. Our analysis revealed that donors from the recent (2006–2012) period were more likely to have increased body mass index (26.4± v. 25.0 ± 4.8, p = 0.003), smoking history (57.0% v. 27.2%, p < 0.001), coronary artery disease (14.3% v. 3.2%, p = 0.015) and dyslipidemia (19.1% v. 4.2%, p < 0.001), but less likely to have concurrent infection (1.1% v. 7.9%, p < 0.001) than those from the earlier period.
Our data suggest that the characteristics and comorbidities of brain-dead organ donors have somewhat deteriorated over the last decade. Further studies are needed to evaluate the impact of these health attributes on donated organ utilization and outcomes.
Comme la prévalence de l’obésité et du syndrome métabolique est actuellement en hausse dans la population générale, nous avons voulu évaluer, dans une étude longitudinale, les comorbidités et les caractéristiques de la population de donneurs d’organes en état de mort cérébrale au fil du temps.
Nous avons comparé la santé globale et les caractéristiques de base des donneurs d’organes de 2000–2005 et de 2006–2012 au moyen de notre base de données prospective sur les greffes. Des analyses descriptives et comparatives des 2 cohortes ont été effectuées.
Au total, 1040 donneurs d’organes en état de mort cérébrale ont été inclus dans notre analyse : 496 de la période de 2000–2005 et 544 de la période de 2006–2012. Notre analyse a révélé que les donneurs de la période récente (2006–2012) étaient plus susceptibles d’avoir un indice de masse corporelle élevé (26,4 ± 6,0 c. 25,0 ± 4,8, p = 0,003), des antécédents de tabagisme (57,0 % contre 27,2 %, p < 0,001), une coronaropathie (14,3 % c. 3,2 %, p = 0,015) et une dyslipidémie (19,1 % c. 4,2 %, p < 0,001), mais moins susceptibles d’avoir une infection concomitante (1,1 % c. 7,9 %, p < 0,001) que ceux de la période antérieure.
Nos données semblent indiquer que les caractéristiques et les comorbidités des donneurs d’organes en état de mort cérébrale se sont quelque peu détériorées au cours de la dernière décennie. D’autres études sont nécessaires pour évaluer l’incidence de ces caractéristiques de santé sur l’utilisation des organes donnés et les résultats.
