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Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia

by Bao, Min , Rosas, Ivan O , Douglas, Ivor S , Waters, Michael , Malhotra, Atul , Bräu, Norbert , Savic, Sinisa , Go, Ronaldo C , Hunter, Bradley D , Tsai, Larry , Dimonaco, Sophie , Ustianowski, Andrew , Aziz, Mariam S , Graham, Emily , Cubillo Gracian, Antonio , Matharu, Balpreet , Skiest, Daniel , De La Zerda, David J , Spotswood, Helen , Cooper, Nichola , Youngstein, Taryn , Bhagani, Sanjay , Del Sorbo, Lorenzo

in Adult / Adverse events / Aged / Antibodies, Monoclonal, Humanized - adverse effects / Antibodies, Monoclonal, Humanized - therapeutic use / Body weight / Case reports / Clinical trials / Coronaviruses / COVID-19 / COVID-19 - complications / COVID-19 - drug therapy / COVID-19 - mortality / COVID-19 - therapy / Double-Blind Method / Female / Hospital Mortality / Hospitalization / Humans / Immunosuppressive agents / Infusions, Intravenous / Intensive Care Units / Interleukin 6 / Intravenous administration / Male / Middle Aged / Monoclonal antibodies / Mortality / Original / Placebos / Pneumonia / Receptors, Interleukin-6 - antagonists & inhibitors / Respiration, Artificial / Treatment Failure / Ventilators

2021

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Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia

2021

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Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia

2021

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Journal Article

Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia

Bao, Min,

Rosas, Ivan O,

Douglas, Ivor S,

Waters, Michael,

Malhotra, Atul,

Bräu, Norbert,

Savic, Sinisa,

Go, Ronaldo C,

Hunter, Bradley D,

Tsai, Larry,

Dimonaco, Sophie,

Ustianowski, Andrew,

Aziz, Mariam S,

Graham, Emily,

Cubillo Gracian, Antonio,

Matharu, Balpreet,

Skiest, Daniel,

De La Zerda, David J,

Spotswood, Helen,

Cooper, Nichola,

Youngstein, Taryn,

Bhagani, Sanjay,

Del Sorbo, Lorenzo

2021

Overview

In this randomized trial involving 438 hospitalized patients with severe Covid-19 pneumonia, the use of the monoclonal antibody tocilizumab did not result in significantly better clinical status or lower mortality than placebo at 28 days.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Adverse events

/ Aged

/ Antibodies, Monoclonal, Humanized - adverse effects

/ Antibodies, Monoclonal, Humanized - therapeutic use

/ Body weight

/ Case reports