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Intensive Diabetes Therapy and Glomerular Filtration Rate in Type 1 Diabetes
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Intensive Diabetes Therapy and Glomerular Filtration Rate in Type 1 Diabetes
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Journal Article
Intensive Diabetes Therapy and Glomerular Filtration Rate in Type 1 Diabetes
2011
Overview
Persons with type 1 diabetes are at high risk for kidney disease. In this study, intensive diabetes therapy administered early in the course of type 1 diabetes reduced the long-term risk of an impaired glomerular filtration rate.
An impaired glomerular filtration rate (GFR) is the final common pathway of diabetic kidney disease. Once the GFR is impaired, cardiovascular disease events and progression to end-stage renal disease occur at unacceptably high rates, even with proven medical management.
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This underscores the need for the primary prevention of impaired GFR in persons with diabetes.
The Diabetes Control and Complications Trial (DCCT) and the observational study that followed it, the Epidemiology of Diabetes Interventions and Complications (EDIC) study, showed that intensive diabetes therapy that lowered glycated hemoglobin levels reduced the risk of microalbuminuria and macroalbuminuria among persons with type 1 . . .
Publisher
Massachusetts Medical Society
Subject
/ Biological and medical sciences
/ Diabetes
/ Diabetes mellitus (insulin dependent)
/ Diabetes Mellitus, Type 1 - blood
/ Diabetes Mellitus, Type 1 - drug therapy
/ Diabetes Mellitus, Type 1 - physiopathology
/ Diabetes. Impaired glucose tolerance
/ Diabetic Nephropathies - epidemiology
/ Endocrine pancreas. Apud cells (diseases)
/ Etiopathogenesis. Screening. Investigations. Target tissue resistance
/ Female
/ Glomerular Filtration Rate - drug effects
/ Glycated Hemoglobin - analysis
/ Humans
/ Hypoglycemic Agents - administration & dosage
/ Insulin - administration & dosage
/ Kidney Failure, Chronic - epidemiology
/ Male
