Journal Article

Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

Van Vlierberghe, Pieter, Dolgalev, Igor, Vance, Gail, Rowe, Jacob M, Cherry, Athena, Patel, Jay P, Luger, Selina, Melnick, Ari, Socci, Nicholas D, Gallagher, Robert E, Heguy, Adriana, Huberman, Kety, Paietta, Elisabeth, Thomas, Sabrena, Aminova, Olga, Lazarus, Hillard M, Levine, Ross L, Abdel-Wahab, Omar, Ferrando, Adolfo, Figueroa, Maria E, Racevskis, Janis, Tallman, Martin S, Viale, Agnes, Gönen, Mithat, Fernandez, Hugo, Cheng, Janice, Sun, Zhuoxin, Ketterling, Rhett P, van den Brink, Marcel R.M, Higgins, Rodney R, Litzow, Mark

2012

Overview

Malignant cells in most patients with acute myeloid leukemia have mutations. Cytogenetic classification yields some prognostic information, but the intermediate-risk group is heterogeneous. Mutational analysis identifies intermediate-risk patients who may benefit from high-dose therapy. Previous studies have highlighted the clinical and biologic heterogeneity of acute myeloid leukemia (AML). 1 – 4 However, a relatively small number of cytogenetic and molecular lesions have sufficient relevance to influence clinical practice. 5 The prognostic relevance of cytogenetic abnormalities has led to the widespread adoption of risk stratification, with patients divided into three cytogenetically defined risk groups with significant differences in overall survival. 6 More recently, FLT3, NPM1, and CEBPA mutational analysis was shown to improve risk stratification for patients who do not have karyotypic abnormalities. 7 Although progress has been made in defining prognostic markers for AML, a substantial percentage of patients . . .

• Publisher: Massachusetts Medical Society
• Subject: Acute myeloid leukemia / Adolescent / Adult / Antibiotics, Antineoplastic - administration & dosage / Biological and medical sciences / Chemotherapy / Clinical trials / Daunorubicin / Daunorubicin - administration & dosage / Deoxyribonucleic acid / DNA / DNA Fingerprinting / DNA Mutational Analysis / Gene Duplication / General aspects / Hematologic and hematopoietic diseases / Humans / Induction Chemotherapy / Induction therapy / Kaplan-Meier Estimate / Leukemia, Myeloid, Acute - drug therapy / Leukemia, Myeloid, Acute - genetics / Leukemia, Myeloid, Acute - mortality / Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis / Medical prognosis / Medical research / Medical sciences / Middle Aged / Mutation / Myeloid leukemia / Nucleophosmin / Patients / Prognosis / Remission / Risk Assessment - methods / Translocation / Translocation, Genetic / Young Adult