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Leptin responses to antecedent exercise and hypoglycemia in healthy and type 1 diabetes mellitus men and women
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Leptin responses to antecedent exercise and hypoglycemia in healthy and type 1 diabetes mellitus men and women
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Journal Article
Leptin responses to antecedent exercise and hypoglycemia in healthy and type 1 diabetes mellitus men and women
2003
Overview
These studies examined the effects of hypoglycemia or exercise on leptin levels in 47 (23 women, 24 men) healthy (age 26±2 years, body mass index 23±0.5 kg·m
−2) and type 1 diabetes mellitus (T1DM) subjects (age 29±2 years, body mass index 27±2 kg·m
−2). In Study 1, healthy and T1DM subjects were exposed to morning and afternoon 120-min hyperinsulinemic hypoglycemic (∼50 mg/dl) or euglycemic (∼90 mg/dl) clamps. In Study 2, healthy subjects were studied during morning and afternoon 90-min exercise bouts at 50% VO
2max. In Study 1, basal levels of leptin were significantly greater in T1DM vs. the healthy subjects (13.8±3 vs. 5.4±1 ng/dl;
P<.05). However, during the last 30 min of morning hypoglycemia, plasma leptin levels significantly decreased from 5.4±1 to 4.0±1 ng/dl (
P<.05) and remained low during afternoon hypoglycemia (4.3±1 ng/dl) in healthy but not T1DM subjects. In Study 2, plasma leptin levels did not significantly change during exercise the bout in healthy men, but significantly decreased 3 h after morning exercise, and continued to decrease during afternoon exercise in healthy women (
P<.0001). Thus, plasma leptin levels decrease in response to hypoglycemia in healthy but not T1DM subjects. However, T1DM patients do have increased basal leptin levels compared to healthy man. Lastly, there is a marked sexual dimorphism in plasma leptin responses to repeated episodes of exercise.
Publisher
Elsevier Inc,Elsevier Science,Elsevier Limited
Subject
/ Adult
/ Biological and medical sciences
/ Circadian Rhythm - physiology
/ Diabetes
/ Diabetes Mellitus, Type 1 - blood
/ Diabetes Mellitus, Type 1 - physiopathology
/ Diabetes. Impaired glucose tolerance
/ Diet
/ Endocrine pancreas. Apud cells (diseases)
/ Etiopathogenesis. Screening. Investigations. Target tissue resistance
/ Exercise
/ Female
/ Glucose
/ Humans
/ Hypoglycemia - physiopathology
/ Insulin
/ Leptin
/ Male
/ Plasma
/ Rodents
/ Stress, Physiological - blood
/ Stress, Physiological - physiopathology
/ Women
