Asset Details
Do you wish to reserve the book?
Folate, alcohol, ADH1B and ALDH2 and colorectal cancer risk
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Folate, alcohol, ADH1B and ALDH2 and colorectal cancer risk
Do you wish to request the book?
Folate, alcohol, ADH1B and ALDH2 and colorectal cancer risk
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Folate, alcohol, ADH1B and ALDH2 and colorectal cancer risk
2021
Overview
There is limited evidence on the interaction by
2 (
) (rs1229984) and
2 (
) (rs671) regarding the associations of alcohol and a methyl diet (low folate and high alcohol intake) with cancer risk, partly because of rare polymorphisms in Western populations.
In a case-control study, we estimated the ORs and 95 % CIs to evaluate the associations of
and
genotypes with colorectal cancer (CRC) and the joint association between methyl diets and
and
polymorphisms with CRC risk using logistic regression models.
A hospital-based case-control study.
In total, 1001 CRC cases and 899 cancer-free controls admitted to two university hospitals.
We found that alcohol intake increased the risk of CRC; OR (95 % CI) was 2·02 (1·41, 2·87) for ≥60 g/d drinkers compared with non-drinkers (
< 0·001). The associations for two polymorphisms with CRC were not statistically significant. However, we found a potential interaction of
with methyl diets and CRC. We observed a 9·08-fold (95 % CI 1·93, 42·60) higher risk of CRC for low-methyl diets compared with high-methyl diets among individuals with an
allele of
, but the association was not apparent among those with
(
= 0·02).
Our data support the evidence that gene-methyl diet interactions may be involved in CRC risk in East Asian populations, showing that a low-methyl diet increased the risk of CRC among individuals with an
allele of
.
