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Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization
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Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization
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Journal Article
Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization
2015
Overview
Andrew Koh and colleagues report that gut anaerobes in adult mice prevent
Candida albicans
colonization by inducing an antimicrobial peptide.
Candida albicans
colonization is required for invasive disease
1
,
2
,
3
. Unlike humans, adult mice with mature intact gut microbiota are resistant to
C. albicans
gastrointestinal (GI) colonization
2
,
4
, but the factors that promote
C. albicans
colonization resistance are unknown. Here we demonstrate that commensal anaerobic bacteria—specifically clostridial Firmicutes (clusters IV and XIVa) and Bacteroidetes—are critical for maintaining
C. albicans
colonization resistance in mice. Using
Bacteroides thetaiotamicron
as a model organism, we find that hypoxia-inducible factor-1α (HIF-1α), a transcription factor important for activating innate immune effectors, and the antimicrobial peptide LL-37 (CRAMP in mice) are key determinants of
C. albicans
colonization resistance. Although antibiotic treatment enables
C. albicans
colonization, pharmacologic activation of colonic
Hif1a
induces CRAMP expression and results in a significant reduction of
C. albicans
GI colonization and a 50% decrease in mortality from invasive disease. In the setting of antibiotics,
Hif1a
and
Camp
(which encodes CRAMP) are required for
B. thetaiotamicron
–induced protection against
C. albicans
colonization of the gut. Thus, modulating
C. albicans
GI colonization by activation of gut mucosal immune effectors may represent a novel therapeutic approach for preventing invasive fungal disease in humans.
Publisher
Nature Publishing Group US
Subject
/ 64/60
/ 82/29
/ Animals
/ Anti-Bacterial Agents - pharmacology
/ Anti-Bacterial Agents - therapeutic use
/ Antimicrobial Cationic Peptides
/ Bacteria
/ Candida albicans - drug effects
/ Candida albicans - growth & development
/ Female
/ Gastrointestinal Tract - drug effects
/ Gastrointestinal Tract - microbiology
/ Gastrointestinal Tract - pathology
/ Humans
/ Hypoxia-Inducible Factor 1, alpha Subunit - genetics
/ Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
/ letter
