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Formalin-inactivated bovine RSV vaccine influences antibody levels in bronchoalveolar lavage fluid and disease outcome in experimentally infected calves

by Kalina, Warren V. , Woolums, Amelia R. , Gershwin, Laurel J.

in Animals / Antibodies, Viral - biosynthesis / Antibodies, Viral - blood / Antibody Formation / Applied microbiology / BALF / Biological and medical sciences / Bronchoalveolar Lavage / BRSV / Cattle / Cattle Diseases - immunology / Cattle Diseases - metabolism / Cattle Diseases - prevention & control / FI-BRSV / Formaldehyde - pharmacology / Fundamental and applied biological sciences. Psychology / Immunization / Infections / Microbiology / Proteins / Respiratory diseases / Respiratory syncytial virus / Respiratory Syncytial Virus Infections - metabolism / Respiratory Syncytial Virus Infections - prevention & control / Respiratory Syncytial Virus Infections - veterinary / Respiratory Syncytial Virus Vaccines - administration & dosage / Respiratory Syncytial Virus Vaccines - immunology / Respiratory Syncytial Virus, Bovine - drug effects / Respiratory Syncytial Virus, Bovine - immunology / Studies / Treatment Outcome / Vaccines / Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) / Vaccines, Attenuated - administration & dosage / Vaccines, Attenuated - immunology

2005

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Formalin-inactivated bovine RSV vaccine influences antibody levels in bronchoalveolar lavage fluid and disease outcome in experimentally infected calves

by Kalina, Warren V. , Woolums, Amelia R. , Gershwin, Laurel J.

2005

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Formalin-inactivated bovine RSV vaccine influences antibody levels in bronchoalveolar lavage fluid and disease outcome in experimentally infected calves

by Kalina, Warren V. , Woolums, Amelia R. , Gershwin, Laurel J.

2005

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Journal Article

Formalin-inactivated bovine RSV vaccine influences antibody levels in bronchoalveolar lavage fluid and disease outcome in experimentally infected calves

Kalina, Warren V.,

Woolums, Amelia R.,

Gershwin, Laurel J.

2005

Overview

Respiratory syncytial virus (RSV) causes severe respiratory disease in calves and human infants. In response to outbreaks, formalin inactivated (FI)-RSV vaccines were developed and found to exacerbate disease following a live RSV infection. We have reproduced vaccination induced disease enhancement in calves and screened various antibody isotypes in bronchoalveolar lavage fluid (BALF) from two studies: one with disease enhancement and another where moderate protection resulted from FI-bovine RSV (BRSV) vaccination. Semi-protected vaccinated calves produced BRSV-specific BALF IgG1, but not IgA and IgG2 prior to infection; whereas, calves with enhanced disease failed to develop BRSV-specific IgG1 in BALF. Ultimately, the formulation and delivery of RSV vaccines influences protective antibody levels in respiratory secretions.

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Publisher

Elsevier Ltd,Elsevier,Elsevier Limited

Subject

Animals

/ Antibodies, Viral - biosynthesis

/ Antibodies, Viral - blood

/ Antibody Formation

/ Applied microbiology

/ BALF

/ Biological and medical sciences